8AH2

Crystal structure of human 14-3-3 zeta fused to the NPM1 peptide including phosphoserine-48

Summary for 8AH2

Entry DOI	10.2210/pdb8ah2/pdb
Descriptor	14-3-3 protein zeta/delta,Nucleophosmin (2 entities in total)
Functional Keywords	14-3-3, nucleophosmin 1, npm1, b23, numatrin, ser48, phosphoserine binder, phosphothreonine binder, pentamer, phosphorylation, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	55274.11
Authors	Boyko, K.M.,Kapitonova, A.A.,Tugaeva, K.V.,Varfolomeeva, L.A.,Sluchanko, N.N. (deposition date: 2022-07-20, release date: 2022-09-14, Last modification date: 2024-01-31)
Primary citation	Kapitonova, A.A.,Tugaeva, K.V.,Varfolomeeva, L.A.,Boyko, K.M.,Cooley, R.B.,Sluchanko, N.N. Structural basis for the recognition by 14-3-3 proteins of a conditional binding site within the oligomerization domain of human nucleophosmin. Biochem.Biophys.Res.Commun., 627:176-183, 2022 Cited by PubMed: 36041327 DOI: 10.1016/j.bbrc.2022.08.047 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation