7ONI

Structure of Neddylated CUL5 C-terminal region-RBX2-ARIH2*

Summary for 7ONI

• Entry DOI: 10.2210/pdb7oni/pdb
• EMDB information: 12995
• Descriptor: Cullin-5, E3 ubiquitin-protein ligase ARIH2, RING-box protein 2, ... (5 entities in total)
• Functional Keywords: cul5, nedd8, ubq, ubiquitin, arih2, rbx2, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 171078.74

Authors

Kostrhon, S.P.,prabu, J.R.,Schulman, B.A. (deposition date: 2021-05-25, release date: 2021-09-15, Last modification date: 2021-10-06)

• Primary citation: Kostrhon, S.,Prabu, J.R.,Baek, K.,Horn-Ghetko, D.,von Gronau, S.,Klugel, M.,Basquin, J.,Alpi, A.F.,Schulman, B.A.; CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.; Nat.Chem.Biol., 17:1075-1083, 2021; PubMed: 34518685; DOI: 10.1038/s41589-021-00858-8

Experimental method

ELECTRON MICROSCOPY (3.4 Å)