Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7ONI

Structure of Neddylated CUL5 C-terminal region-RBX2-ARIH2*

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005262	molecular_function	calcium channel activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0016567	biological_process	protein ubiquitination
C	0019005	cellular_component	SCF ubiquitin ligase complex
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0038023	molecular_function	signaling receptor activity
C	0038026	biological_process	reelin-mediated signaling pathway
C	0038128	biological_process	ERBB2 signaling pathway
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0070588	biological_process	calcium ion transmembrane transport
C	0070979	biological_process	protein K11-linked ubiquitination
C	0090734	cellular_component	site of DNA damage
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	2001222	biological_process	regulation of neuron migration
H	0000151	cellular_component	ubiquitin ligase complex
H	0000209	biological_process	protein polyubiquitination
H	0004842	molecular_function	ubiquitin-protein transferase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0008270	molecular_function	zinc ion binding
H	0016567	biological_process	protein ubiquitination
H	0016740	molecular_function	transferase activity
H	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
H	0031624	molecular_function	ubiquitin conjugating enzyme binding
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0046872	molecular_function	metal ion binding
H	0048588	biological_process	developmental cell growth
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0070534	biological_process	protein K63-linked ubiquitination
H	0070936	biological_process	protein K48-linked ubiquitination
H	0071425	biological_process	hematopoietic stem cell proliferation
H	1903955	biological_process	positive regulation of protein targeting to mitochondrion
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005829	cellular_component	cytosol
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0006508	biological_process	proteolysis
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0008104	biological_process	protein localization
N	0009653	biological_process	anatomical structure morphogenesis
N	0016567	biological_process	protein ubiquitination
N	0019941	biological_process	modification-dependent protein catabolic process
N	0030162	biological_process	regulation of proteolysis
N	0031386	molecular_function	protein tag activity
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0036211	biological_process	protein modification process
N	0045116	biological_process	protein neddylation
N	0070062	cellular_component	extracellular exosome
R	0005507	molecular_function	copper ion binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0008270	molecular_function	zinc ion binding
R	0016567	biological_process	protein ubiquitination
R	0016740	molecular_function	transferase activity
R	0019788	molecular_function	NEDD8 transferase activity
R	0030968	biological_process	endoplasmic reticulum unfolded protein response
R	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
R	0038026	biological_process	reelin-mediated signaling pathway
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0043687	biological_process	post-translational protein modification
R	0045116	biological_process	protein neddylation
R	0046872	molecular_function	metal ion binding
R	0051775	biological_process	response to redox state
R	0061630	molecular_function	ubiquitin protein ligase activity
R	0061663	molecular_function	NEDD8 ligase activity
R	0070979	biological_process	protein K11-linked ubiquitination
R	0097602	molecular_function	cullin family protein binding
R	2001222	biological_process	regulation of neuron migration

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KerVeEkegIPpqqQrLIYsGkqmnD

Chain	Residue	Details
N	LYS27-ASP52

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CkHdFCwmCL

Chain	Residue	Details
H	CYS318-LEU327

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKeqIewLIEHkYIrRdesdintFiYmA

Chain	Residue	Details
C	ILE753-ALA780

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Interaction with UBE1C => ECO:0000269\|PubMed:14690597

Chain	Residue	Details
N	LEU8
N	ILE44

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: (Microbial infection) Deamidated glutamine => ECO:0000269\|PubMed:20688984, ECO:0000269\|PubMed:21903097, ECO:0000269\|PubMed:23175788, ECO:0000269\|PubMed:23589306, ECO:0000269\|PubMed:26632597

Chain	Residue	Details
N	GLN40
R	CYS88
R	CYS99
R	CYS102
R	CYS53
R	CYS61
R	CYS64
R	CYS73
R	CYS80
R	HIS82
R	HIS85
R	CYS87

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P29595

Chain	Residue	Details
N	LYS48

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
N	GLY76

site_id	SWS_FT_FI5
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01221

Chain	Residue	Details
H	CYS139
H	CYS233
H	CYS249
H	CYS252
H	CYS257
H	CYS260
H	HIS265
H	CYS270
H	CYS297
H	CYS300
H	CYS315
H	CYS142
H	CYS318
H	CYS323
H	CYS326
H	HIS333
H	CYS340
H	CYS156
H	HIS158
H	CYS161
H	CYS164
H	CYS183
H	CYS188
H	CYS228

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17525332, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
H	SER353

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)