7P2V

Crystal structure of Schistosoma mansoni HDAC8 in complex with a 4-chlorophenyl-spiroindoline capped hydroxamate-based inhibitor, bound to a novel site

Summary for 7P2V

Entry DOI	10.2210/pdb7p2v/pdb
Descriptor	Histone deacetylase 8, ZINC ION, POTASSIUM ION, ... (7 entities in total)
Functional Keywords	smhdac8, novel binding-site, hdaci, histone-deacetilase inhibitor complex, hydrolase
Biological source	Schistosoma mansoni (Blood fluke)
Total number of polymer chains	1
Total formula weight	50702.04
Authors	Saccoccia, F.,Gemma, S.,Campiani, G.,Ruberti, G. (deposition date: 2021-07-06, release date: 2022-07-20, Last modification date: 2024-01-31)
Primary citation	Saccoccia, F.,Pozzetti, L.,Gimmelli, R.,Butini, S.,Guidi, A.,Papoff, G.,Giannaccari, M.,Brogi, S.,Scognamiglio, V.,Gemma, S.,Ruberti, G.,Campiani, G. Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors. J.Biol.Chem., 298:102375-102375, 2022 Cited by PubMed: 35970392 DOI: 10.1016/j.jbc.2022.102375 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation