4N84

Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS

Summary for 4N84

• Entry DOI: 10.2210/pdb4n84/pdb
• Related: 3CH8 3NKX 4IEA 4IHL 4N7G 4N7Y
• Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S (3 entities in total)
• Functional Keywords: 14-3-3, adaptor protein, protein-protein interaction, cross-link, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P63104
• Total number of polymer chains: 4
• Total formula weight: 54748.01

Authors

Bier, D.,Glas, A.,Hahne, G.,Grossmann, T.,Ottmann, C. (deposition date: 2013-10-17, release date: 2014-02-19, Last modification date: 2014-03-12)

• Primary citation: Glas, A.,Bier, D.,Hahne, G.,Rademacher, C.,Ottmann, C.,Grossmann, T.N.; Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction.; Angew.Chem.Int.Ed.Engl., 53:2489-2493, 2014; PubMed: 24504455; DOI: 10.1002/anie.201310082

Experimental method

X-RAY DIFFRACTION (2.5 Å)