4N84

Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	14-3-3 protein zeta/delta	polymer	230	26260.7	2	UniProt (P63104) Pfam (PF00244)	Homo sapiens (human)	Protein kinase C inhibitor protein 1, KCIP-1
2	C, D (C, E)	Exoenzyme S	polymer	10	1113.3	2	UniProt (Q93SQ3)	Pseudomonas aeruginosa
3	E, F, G, H (A, B, C, E)	water	water		18.0	42	Chemie (HOH)

Sequence modifications

A, B: 1 - 230 (UniProt: P63104)

PDB	External Database	Details
Gly 0	-	expression tag
-	Leu 206	deletion

C, E: 421 - 430 (UniProt: Q93SQ3)

PDB	External Database	Details
Mkd 422	Leu 422	engineered mutation
Mkd 425	Ala 425	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	54748.0
All*	Total formula weight	54748.0

*Water molecules are not included.