7P2S
Crystal structure of Schistosoma mansoni HDAC8 in complex with a tricyclic thieno[3,2-b]indole capped hydroxamate-based inhibitor, chlorine derivative
Summary for 7P2S
Entry DOI | 10.2210/pdb7p2s/pdb |
Descriptor | Histone deacetylase 8, ZINC ION, POTASSIUM ION, ... (5 entities in total) |
Functional Keywords | inhibitor histone deacetylase (hdaci), complex schistosoma mansoni hdac8 + inhibitor, active-site., hydrolase |
Biological source | Schistosoma mansoni (Blood fluke) |
Total number of polymer chains | 1 |
Total formula weight | 50402.33 |
Authors | Saccoccia, F.,Gemma, S.,Campiani, G.,Ruberti, G. (deposition date: 2021-07-06, release date: 2022-07-27, Last modification date: 2024-01-31) |
Primary citation | Saccoccia, F.,Pozzetti, L.,Gimmelli, R.,Butini, S.,Guidi, A.,Papoff, G.,Giannaccari, M.,Brogi, S.,Scognamiglio, V.,Gemma, S.,Ruberti, G.,Campiani, G. Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors. J.Biol.Chem., 298:102375-102375, 2022 Cited by PubMed: 35970392DOI: 10.1016/j.jbc.2022.102375 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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