7P2S

Crystal structure of Schistosoma mansoni HDAC8 in complex with a tricyclic thieno[3,2-b]indole capped hydroxamate-based inhibitor, chlorine derivative

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004407	molecular_function	histone deacetylase activity
A	0005634	cellular_component	nucleus
A	0006325	biological_process	chromatin organization
A	0006351	biological_process	DNA-templated transcription
A	0016787	molecular_function	hydrolase activity
A	0031507	biological_process	heterochromatin formation
A	0040029	biological_process	epigenetic regulation of gene expression
A	0046872	molecular_function	metal ion binding
A	0141221	molecular_function	histone deacetylase activity, hydrolytic mechanism