6ZTJ
 
 | | E. coli 70S-RNAP expressome complex in NusG-coupled state (38 nt intervening mRNA) | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ... | | 著者 | Webster, M.W, Takacs, M, Weixlbaumer, A. | | 登録日 | 2020-07-20 | | 公開日 | 2020-09-16 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis of transcription-translation coupling and collision in bacteria.
Science, 369, 2020
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7CKM
 | | Structure of Machupo virus polymerase bound to Z matrix protein (monomeric complex) | | 分子名称: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | | 著者 | Xu, X, Peng, R, Peng, Q, Shi, Y. | | 登録日 | 2020-07-17 | | 公開日 | 2021-05-05 | | 最終更新日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals
Nat Microbiol, 6, 2021
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7CKL
 | | Structure of Lassa virus polymerase bound to Z matrix protein | | 分子名称: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | | 著者 | Xu, X, Peng, R, Peng, Q, Shi, Y. | | 登録日 | 2020-07-17 | | 公開日 | 2021-05-05 | | 最終更新日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals
Nat Microbiol, 6, 2021
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7CK5
 | | Solution structure of 28 amino acid polypeptide (354-381) in Plantago asiatica mosaic virus replicase bound to SDS micelle | | 分子名称: | PlAMV replicase peptide from RNA-dependent RNA polymerase | | 著者 | Komatsu, K, Sasaki, N, Yoshida, T, Suzuki, K, Masujima, Y, Hashimoto, M, Watanabe, S, Tochio, N, Kigawa, T, Yamaji, Y, Oshima, K, Namba, S, Nelson, R, Arie, T. | | 登録日 | 2020-07-15 | | 公開日 | 2021-07-21 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Identification of a Proline-Kinked Amphipathic alpha-Helix Downstream from the Methyltransferase Domain of a Potexvirus Replicase and Its Role in Virus Replication and Perinuclear Complex Formation.
J.Virol., 95, 2021
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6XRE
 | | Structure of the p53/RNA polymerase II assembly | | 分子名称: | Cellular tumor antigen p53, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11-a, ... | | 著者 | Liou, S.-H, Singh, S, Singer, R.H, Coleman, R.A, Liu, W. | | 登録日 | 2020-07-12 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structure of the p53/RNA polymerase II assembly.
Commun Biol, 4, 2021
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6XQB
 | | SARS-CoV-2 RdRp/RNA complex | | 分子名称: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Liu, B, Shi, W, Yang, Y. | | 登録日 | 2020-07-09 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure of SARS-CoV-2 RdRp/RNA complex at 3.4 Angstroms resolution
To Be Published
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6XIP
 | | The 1.5 A Crystal Structure of the Co-factor Complex of NSP7 and the C-terminal Domain of NSP8 from SARS CoV-2 | | 分子名称: | 1,2-ETHANEDIOL, Non-structural protein 7, Non-structural protein 8 | | 著者 | Wilamowski, M, Kim, Y, Jedrzejczak, R, Maltseva, N, Endres, M, Godzik, A, Michalska, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2020-06-20 | | 公開日 | 2020-07-01 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication.
Biophys.J., 120, 2021
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6XEZ
 | | Structure of SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | | 著者 | Chen, J, Malone, B, Llewellyn, E.C, Campbell, E.A, Darst, S.A. | | 登録日 | 2020-06-14 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex.
Cell, 182, 2020
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7CBT
 | | The crystal structure of SARS-CoV-2 main protease in complex with GC376 | | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase | | 著者 | Shi, Y, Peng, G. | | 登録日 | 2020-06-13 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.346 Å) | | 主引用文献 | The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract.
Emerg Microbes Infect, 10, 2021
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6XD1
 | | Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-640 | | 分子名称: | (2R)-4-(butyl{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}carbamoyl)-1-(2,2-diphenylpropanoyl)piperazine-2-carboxylic acid, RNA-dependent RNA polymerase, ZINC ION | | 著者 | Arora, R, Benson, T.E, Liew, C.W, Lescar, J. | | 登録日 | 2020-06-09 | | 公開日 | 2020-09-23 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.954 Å) | | 主引用文献 | Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies.
J.Virol., 94, 2020
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6XD0
 | | Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-434 | | 分子名称: | 2-[({2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)amino]-2,3-dihydro-1H-indene-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Arora, R, Benson, T.E, Liew, C.W, Lescar, J. | | 登録日 | 2020-06-09 | | 公開日 | 2020-09-23 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.012 Å) | | 主引用文献 | Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies.
J.Virol., 94, 2020
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6Z8K
 | | La Crosse virus polymerase at elongation mimicking stage | | 分子名称: | La Crosse virus 3' vRNA (1-16), La Crosse virus 5' vRNA (9-16), La Crosse virus 5' vRNA 1-10, ... | | 著者 | Arragain, B, Effantin, G, Schoehn, G, Cusack, S, Malet, H. | | 登録日 | 2020-06-02 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
Nat Commun, 11, 2020
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6Z6B
 | | Structure of full-length La Crosse virus L protein (polymerase) | | 分子名称: | RNA (5'-R(*GP*CP*UP*AP*CP*UP*AP*A)-3'), RNA (5'-R(P*AP*GP*UP*AP*GP*UP*GP*UP*GP*C)-3'), RNA (5'-R(P*UP*UP*AP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3'), ... | | 著者 | Cusack, S, Gerlach, P, Reguera, J. | | 登録日 | 2020-05-28 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.961 Å) | | 主引用文献 | Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
Nat Commun, 11, 2020
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6Z6G
 | | Cryo-EM structure of La Crosse virus polymerase at pre-initiation stage | | 分子名称: | 3'vRNA 1-16, 5'vRNA 1-10, 5'vRNA 9-16, ... | | 著者 | Arragain, B, Effantin, G, Gerlach, P, Reguera, J, Schoehn, G, Cusack, S, Malet, H. | | 登録日 | 2020-05-28 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
Nat Commun, 11, 2020
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7C2K
 | | COVID-19 RNA-dependent RNA polymerase pre-translocated catalytic complex | | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA (29-MER), ... | | 著者 | Wang, Q, Gao, Y, Ji, W, Mu, A, Rao, Z. | | 登録日 | 2020-05-07 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.
Cell, 182, 2020
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7C21
 | | Crystal structure of Duvenhage virus phosphoprotein C-terminal domain | | 分子名称: | Phosphoprotein | | 著者 | Sugiyama, A, Jiang, X, Maenaka, K, Yao, M, Ose, T. | | 登録日 | 2020-05-06 | | 公開日 | 2021-03-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural comparison of the C-terminal domain of functionally divergent lyssavirus P proteins.
Biochem.Biophys.Res.Commun., 529, 2020
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7C20
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6YYT
 | | Structure of replicating SARS-CoV-2 polymerase | | 分子名称: | RNA product, ZINC ION, nsp12, ... | | 著者 | Hillen, H.S, Kokic, G, Farnung, L, Dienemann, C, Tegunov, D, Cramer, P. | | 登録日 | 2020-05-06 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structure of replicating SARS-CoV-2 polymerase.
Nature, 584, 2020
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6WQD
 | | The 1.95 A Crystal Structure of the Co-factor Complex of NSP7 and the C-terminal Domain of NSP8 from SARS-CoV-2 | | 分子名称: | 1,2-ETHANEDIOL, Non-structural protein 7, Non-structural protein 8 | | 著者 | Kim, Y, Wilamowski, M, Jedrzejczak, R, Maltseva, N, Endres, M, Godzik, A, Michalska, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2020-04-28 | | 公開日 | 2020-05-06 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication.
Biophys.J., 120, 2021
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7BZF
 | | COVID-19 RNA-dependent RNA polymerase post-translocated catalytic complex | | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA (31-MER), ... | | 著者 | Wang, Q, Gao, Y, Ji, W, Mu, A, Rao, Z. | | 登録日 | 2020-04-27 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.
Cell, 182, 2020
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6YP5
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7BW4
 | | Structure of the RNA-dependent RNA polymerase from SARS-CoV-2 | | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ... | | 著者 | Peng, Q, Peng, R, Shi, Y. | | 登録日 | 2020-04-13 | | 公開日 | 2020-05-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2.
Cell Rep, 31, 2020
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6WJ4
 | | The crystal structure of the 2009/H1N1/California PA endonuclease wild type in complex with SJ000986448 | | 分子名称: | 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-[2-(trifluoromethyl)phenyl]-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... | | 著者 | Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. | | 登録日 | 2020-04-11 | | 公開日 | 2021-04-14 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
Eur.J.Med.Chem., 247, 2023
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6WIQ
 | | Crystal structure of the co-factor complex of NSP7 and the C-terminal domain of NSP8 from SARS CoV-2 | | 分子名称: | Non-structural protein 7, Non-structural protein 8 | | 著者 | Wilamowski, M, Kim, Y, Jedrzejczak, R, Maltseva, N, Endres, M, Godzik, A, Michalska, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2020-04-10 | | 公開日 | 2020-04-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication.
Biophys.J., 120, 2021
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6WIJ
 | | The crystal structure of the 2009/H1N1/California PA endonuclease mutant I38T in complex with SJ000986448 | | 分子名称: | 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-[2-(trifluoromethyl)phenyl]-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... | | 著者 | Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. | | 登録日 | 2020-04-10 | | 公開日 | 2021-04-14 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
Eur.J.Med.Chem., 247, 2023
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