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7CBT

The crystal structure of SARS-CoV-2 main protease in complex with GC376

Summary for 7CBT
Entry DOI10.2210/pdb7cbt/pdb
Descriptor3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total)
Functional Keywordssars-cov-2, main protease, gc376, complex, viral protein
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains2
Total formula weight74798.81
Authors
Shi, Y.,Peng, G. (deposition date: 2020-06-13, release date: 2020-09-02, Last modification date: 2023-11-29)
Primary citationShi, Y.,Shuai, L.,Wen, Z.,Wang, C.,Yan, Y.,Jiao, Z.,Guo, F.,Fu, Z.F.,Chen, H.,Bu, Z.,Peng, G.
The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract.
Emerg Microbes Infect, 10:481-492, 2021
Cited by
PubMed: 33691601
DOI: 10.1080/22221751.2021.1899770
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.346 Å)
Structure validation

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