7CBT
The crystal structure of SARS-CoV-2 main protease in complex with GC376
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | 3C-like proteinase | polymer | 333 | 36913.9 | 2 | UniProt (P0DTD1) Pfam (PF05409) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | pp1ab,ORF1ab polyprotein,3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase,Replicase polyprotein 1ab |
2 | A, B | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid | non-polymer | 485.6 | 2 | Chemie (K36) | |||
3 | water | water | 18.0 | 177 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 306 (UniProt: P0DTD1)
PDB | External Database | Details |
---|---|---|
Met -26 | - | initiating methionine |
His -25 | - | expression tag |
His -24 | - | expression tag |
His -23 | - | expression tag |
His -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
Gly -19 | - | expression tag |
Leu -18 | - | expression tag |
Asn -17 | - | expression tag |
Asp -16 | - | expression tag |
Ile -15 | - | expression tag |
Phe -14 | - | expression tag |
Glu -13 | - | expression tag |
Ala -12 | - | expression tag |
Gln -11 | - | expression tag |
Lys -10 | - | expression tag |
Ile -9 | - | expression tag |
Glu -8 | - | expression tag |
Trp -7 | - | expression tag |
His -6 | - | expression tag |
Glu -5 | - | expression tag |
Gly -4 | - | expression tag |
Gly -3 | - | expression tag |
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 73827.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 971.1 | |
All* | Total formula weight | 74798.8 |