7CKL

Structure of Lassa virus polymerase bound to Z matrix protein

Summary for 7CKL

• Entry DOI: 10.2210/pdb7ckl/pdb
• EMDB information: 30387
• Descriptor: RNA-directed RNA polymerase L, RING finger protein Z, MANGANESE (II) ION, ... (4 entities in total)
• Functional Keywords: lassa virus, polymerase, z protein, replication regulation, viral protein
• Biological source: Lassa mammarenavirus; More
• Total number of polymer chains: 2
• Total formula weight: 264433.05

Authors

Xu, X.,Peng, R.,Peng, Q.,Shi, Y. (deposition date: 2020-07-17, release date: 2021-05-05, Last modification date: 2021-11-17)

• Primary citation: Xu, X.,Peng, R.,Peng, Q.,Wang, M.,Xu, Y.,Liu, S.,Tian, X.,Deng, H.,Tong, Y.,Hu, X.,Zhong, J.,Wang, P.,Qi, J.,Gao, G.F.,Shi, Y.; Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals; Nat Microbiol, 6:921-931, 2021; DOI: 10.1038/s41564-021-00916-w

Experimental method

ELECTRON MICROSCOPY (3.88 Å)