PDB: 9760 件ウェブページステータス検索Chemie searchBIRD

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6CW3	Crystal structure of a yeast SAGA transcriptional coactivator Ada2/Gcn5 HAT subcomplex, crystal form 2 分子名称: Histone acetyltransferase GCN5, Transcriptional adapter 2, ZINC ION, ... 著者 Sun, J, Paduch, M, Kim, S.A, Kramer, R.M, Barrios, A.F, Lu, V, Luke, J, Usatyuk, S, Kossiakoff, A.A, Tan, S. 登録日 2018-03-29 公開日 2018-09-19 最終更新日 2020-03-04 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8ACF	Structure of the argX-117 in complex with a complement C2 fragment at low pH 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... 著者 Olesen, H.G, Andersen, G.R. 登録日 2022-07-05 公開日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-function analysis of ARGX-117, a calcium- and pH-dependent clinical phase complement C2 blocking antibody To be published
8ACI	Structure of ARG-117 Fab in complex with a fragment of complement C2, neutral pH 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ARGX-117 Fab heavy chain, ARGX-117 Fab light chain, ... 著者 Olesen, H.G, Andersen, G.R. 登録日 2022-07-05 公開日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure-function analysis of ARGX-117, a calcium- and pH-dependent clinical phase complement C2 blocking antibody To be published
8BBH	The crystal structure of a mouse Fab fragment TL1 in complex with a human Glucose-6-phosphate isomerase peptide 293-307 分子名称: Glucose-6-phosphate isomerase, Heavy Chain of TL1 Fab fragment, Light Chain of TL1 Fab fragment 著者 Ge, C, Holmdahl, R, Li, T. 登録日 2022-10-13 公開日 2022-12-21 最終更新日 2023-07-05 実験手法 X-RAY DIFFRACTION (1.619 Å) 主引用文献 Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage. Ann Rheum Dis, 82, 2023
5I66	X-ray structure of the Fab fragment of 8B6, a murine monoclonal antibody specific for the human serotonin transporter 分子名称: 8B6 antibody, heavy chain, light chain 著者 Coleman, J.A, Green, E.M, Gouaux, E. 登録日 2016-02-16 公開日 2016-04-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.624 Å) 主引用文献 X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
4MXW	Structure of heterotrimeric lymphotoxin LTa1b2 bound to lymphotoxin beta receptor LTbR and anti-LTa Fab 分子名称: Lymphotoxin-alpha, Lymphotoxin-beta, Tumor necrosis factor receptor superfamily member 3, ... 著者 Sudhamsu, J, Yin, J.P, Hymowitz, S.G. 登録日 2013-09-26 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Dimerization of LT beta R by LT alpha 1 beta 2 is necessary and sufficient for signal transduction. Proc.Natl.Acad.Sci.USA, 110, 2013
6S8J	Structure of ZEBOV GP in complex with 5T0180 antibody 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope Glycoprotein 1, Envelope glycoprotein, ... 著者 Diskin, R, Cohen-Dvashi, H. 登録日 2019-07-10 公開日 2020-02-12 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (2.91 Å) 主引用文献 Structural Basis for a Convergent Immune Response against Ebola Virus. Cell Host Microbe, 27, 2020
6S8I	Structure of ZEBOV GP in complex with 3T0265 antibody 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, Enveloped Glycoprotein 1, ... 著者 Diskin, R, Cohen-Dvashi, H. 登録日 2019-07-10 公開日 2020-02-12 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (2.99 Å) 主引用文献 Structural Basis for a Convergent Immune Response against Ebola Virus. Cell Host Microbe, 27, 2020
6S8D	Structure of ZEBOV GP in complex with 1T0227 antibody 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, Heavy chain, ... 著者 Diskin, R, Cohen-Dvashi, H. 登録日 2019-07-09 公開日 2020-02-12 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.49 Å) 主引用文献 Structural Basis for a Convergent Immune Response against Ebola Virus. Cell Host Microbe, 27, 2020
4MXV	Structure of Lymphotoxin alpha bound to anti-LTa Fab 分子名称: Lymphotoxin-alpha, anti-Lymphotoxin alpha antibody heavy chain, anti-Lymphotoxin alpha antibody light chain 著者 Yin, J.P, Hymowitz, S.G. 登録日 2013-09-26 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Dimerization of LT beta R by LT alpha 1 beta 2 is necessary and sufficient for signal transduction. Proc.Natl.Acad.Sci.USA, 110, 2013
6IAP	structure of human NKp46 in complex with antibody NKp46-1 and NKp46-4 分子名称: Fab NKp46-1 heavy chain, Fab NKp46-1 light chain, Fab NKp46-4 heavy chain, ... 著者 Roussel, A, Amigues, B. 登録日 2018-11-27 公開日 2019-06-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity. Cell, 177, 2019
8JNK	Crystal structure of human ALKBH3 bound to ssDNA through active site crosslink 分子名称: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3, DNA, MANGANESE (II) ION, ... 著者 Zhang, L. 登録日 2023-06-06 公開日 2024-01-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 The Molecular Basis of Human ALKBH3 Mediated RNA N 1 -methyladenosine (m 1 A) Demethylation. Angew.Chem.Int.Ed.Engl., 63, 2024
8JNR	Crystal structure of human ALKBH3 bound to 3mC containing ssDNA through distal crosslink 分子名称: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3, DNA, MANGANESE (II) ION, ... 著者 Zhang, L. 登録日 2023-06-06 公開日 2024-01-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.66 Å) 主引用文献 The Molecular Basis of Human ALKBH3 Mediated RNA N 1 -methyladenosine (m 1 A) Demethylation. Angew.Chem.Int.Ed.Engl., 63, 2024
3FO9	Crystal structure of aldolase antibody 33F12 Fab' in complex with hapten 1,3-diketone 分子名称: 5-{[4-(5-methyl-3-oxohex-4-en-1-yl)phenyl]amino}-5-oxopentanoic acid, Immunoglobulin IGG2A - heavy chain, Immunoglobulin IGG2A - light chain 著者 Zhu, X, Wilson, I.A. 登録日 2008-12-29 公開日 2009-12-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Direct observation of an enamine intermediate in amine catalysis J.Am.Chem.Soc., 131, 2009
1YY8	Crystal structure of the Fab fragment from the monoclonal antibody cetuximab/Erbitux/IMC-C225 分子名称: Cetuximab Fab Heavy chain, Cetuximab Fab Light chain 著者 Li, S, Schmitz, K.R, Jeffrey, P.D, Wiltzius, J.J.W, Kussie, P, Ferguson, K.M. 登録日 2005-02-24 公開日 2005-04-26 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for inhibition of the epidermal growth factor receptor by cetuximab Cancer Cell, 7, 2005
2B4C	Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, T-cell surface glycoprotein CD4, ... 著者 Huang, C, Tang, M, Zhang, M.Y, Majeed, S, Montabana, E, Stanfield, R.L, Dimitrov, D.S, Korber, B, Sodroski, J, Wilson, I.A, Wyatt, R, Kwong, P.D. 登録日 2005-09-23 公開日 2005-11-15 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structure of a V3-containing HIV-1 gp120 core. Science, 310, 2005
1J5O	CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER 分子名称: 5'-D(*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3', 5'-D(*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*A)-3', ANTIBODY (HEAVY CHAIN), ... 著者 Sarafianos, S.G, Das, K, Arnold, E. 登録日 2002-05-24 公開日 2002-06-14 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids. Proc.Natl.Acad.Sci.USA, 96, 1999
7A3R	Crystal structure of dengue 1 virus envelope glycoprotein 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Core protein, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Sharma, A, Vaney, M.C, Guardado-Calvo, P, Duquerroy, S, Rouvinski, A, Rey, F.A. 登録日 2020-08-18 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184, 2021
1N64	Crystal structure analysis of the immunodominant antigenic site on Hepatitis C virus protein bound to mAb 19D9D6 分子名称: Fab 19D9D6 heavy chain, Fab 19D9D6 light chain, Genome polyprotein Capsid protein C 著者 Menez, R, Bossus, M, Muller, B, Sibai, G, Dalbon, P, Ducancel, F, Jolivet-Reynaud, C, Stura, E. 登録日 2002-11-08 公開日 2003-02-25 最終更新日 2013-09-18 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Crystal structure of a hydrophobic immunodominant antigenic site on hepatitis C virus core protein complexed to monoclonal antibody 19D9D6. J.Immunol., 170, 2003
1N8Z	Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Herceptin Fab (antibody) - heavy chain, Herceptin Fab (antibody) - light chain, ... 著者 Cho, H.-S, Mason, K, Ramyar, K.X, Stanley, A.M, Gabelli, S.B, Denney Jr, D.W, Leahy, D.J. 登録日 2002-11-21 公開日 2003-02-18 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Structure of the Extracellular Region of HER2 Alone and in Complex with the Herceptin Fab Nature, 421, 2003
4LVH	Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin 分子名称: CALCIUM ION, Hemagglutinin, MONOCLONAL ANTIBODY H-CHAIN, ... 著者 Kim, K.H, Cho, K.J, Kim, S, Seok, J.H, Lee, J.-H. 登録日 2013-07-26 公開日 2014-04-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Insight into highly conserved h1 subtype-specific epitopes in influenza virus hemagglutinin Plos One, 9, 2014
3T3M	A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Zhu, J, Zhu, J, Springer, T.A. 登録日 2011-07-25 公開日 2012-03-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS Sci Transl Med, 4, 2012
8DW3	Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR16m, and two antibody Fabs, S309 and CR3022 分子名称: Anti-SARS-CoV-2 DARPin SR16m, Antibody S309 light chain, Spike protein S1, ... 著者 Kwon, Y.D, Gorman, J, Kwong, P.D. 登録日 2022-07-30 公開日 2022-12-07 最終更新日 2023-03-15 実験手法 ELECTRON MICROSCOPY (4.26 Å) 主引用文献 A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Nat.Chem.Biol., 19, 2023
1CLZ	IGG FAB (IGG3, KAPPA) FRAGMENT (MBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER 分子名称: IGG FAB (IGG3, KAPPA), METHYL NONANOATE (ESTER), ... 著者 Sheriff, S, Bajorath, J. 登録日 1995-03-15 公開日 1996-08-01 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The x-ray structure of an anti-tumour antibody in complex with antigen. Nat.Struct.Biol., 2, 1995
2XZA	Crystal Structure of recombinant A.17 antibody FAB fragment 分子名称: FAB A.17 HEAVY CHAIN, FAB A.17 LIGHT CHAIN 著者 Carletti, E, Nachon, F, Nicolet, Y, Masson, P, Kurkova, I, Smirnov, I, Friboulet, A, Tramontano, A, Gabibov, A. 登録日 2010-11-24 公開日 2011-09-21 最終更新日 2020-03-11 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Reactibodies Generated by Kinetic Selection Couple Chemical Reactivity with Favorable Protein Dynamics. Proc.Natl.Acad.Sci.USA, 108, 2011

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