8BBH

The crystal structure of a mouse Fab fragment TL1 in complex with a human Glucose-6-phosphate isomerase peptide 293-307

Summary for 8BBH

Entry DOI	10.2210/pdb8bbh/pdb
Descriptor	Glucose-6-phosphate isomerase, Heavy Chain of TL1 Fab fragment, Light Chain of TL1 Fab fragment, ... (4 entities in total)
Functional Keywords	antibody fab fragment, immune system
Biological source	Mus musculus More
Total number of polymer chains	3
Total formula weight	48744.60
Authors	Ge, C.,Holmdahl, R.,Li, T. (deposition date: 2022-10-13, release date: 2022-12-21, Last modification date: 2024-10-23)
Primary citation	Li, T.,Ge, C.,Kramer, A.,Sareila, O.,Leu Agelii, M.,Johansson, L.,Forslind, K.,Lonnblom, E.,Yang, M.,Xu, B.,Li, Q.,Cheng, L.,Bergstrom, G.,Fernandez, G.,Kastbom, A.,Rantapaa-Dahlqvist, S.,Gjertsson, I.,Holmdahl, R. Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage. Ann Rheum Dis, 82:799-808, 2023 Cited by PubMed Abstract: To identify the arthritogenic B cell epitopes of glucose-6-phosphate isomerase (GPI) and their association with rheumatoid arthritis (RA). PubMed: 36858822 DOI: 10.1136/ard-2022-223633 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.619 Å)

Structure validation