1YY8

Crystal structure of the Fab fragment from the monoclonal antibody cetuximab/Erbitux/IMC-C225

Summary for 1YY8

• Entry DOI: 10.2210/pdb1yy8/pdb
• Related: 1YY9
• Descriptor: Cetuximab Fab Light chain, Cetuximab Fab Heavy chain (3 entities in total)
• Functional Keywords: fab fragment; antibody drug; cancer, immune system
• Biological source: Mus musculus, Homo sapiens (house mouse, human); More
• Total number of polymer chains: 4
• Total formula weight: 94026.42

Authors

Li, S.,Schmitz, K.R.,Jeffrey, P.D.,Wiltzius, J.J.W.,Kussie, P.,Ferguson, K.M. (deposition date: 2005-02-24, release date: 2005-04-26, Last modification date: 2023-08-23)

• Primary citation: Li, S.,Schmitz, K.R.,Jeffrey, P.D.,Wiltzius, J.J.W.,Kussie, P.,Ferguson, K.M.; Structural basis for inhibition of the epidermal growth factor receptor by cetuximab; Cancer Cell, 7:301-311, 2005; PubMed: 15837620; DOI: 10.1016/j.ccr.2005.03.003

Experimental method

X-RAY DIFFRACTION (2 Å)