PDB: 902 件ウェブページステータス検索Chemie searchBIRD

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8GCP	Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein 分子名称: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Huang, S.M, Xiong, M.Y, Liu, L, Mu, J, Sheng, C, Sun, J. 登録日 2023-03-02 公開日 2024-01-03 最終更新日 2024-01-10 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
8GDB	Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein 分子名称: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Shenming, H, Mengyao, X, Lei, L, Jianqiang, M, Jinpeng, S. 登録日 2023-03-03 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
8KH4	Cryo-EM structure of the GPR161-Gs complex 分子名称: CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Nie, Y, Qiu, Z, Zheng, S, Chen, S. 登録日 2023-08-21 公開日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling. Nat Commun, 14, 2023
8GG3	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #9 of 20) 分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Papasergi-Scott, M.M, Skiniotis, G. 登録日 2023-03-08 公開日 2024-03-06 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8GFV	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #1 of 20) 分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Papasergi-Scott, M.M, Skiniotis, G. 登録日 2023-03-08 公開日 2024-03-06 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
7RMH	Substance P bound to active human neurokinin 1 receptor in complex with miniGs399 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A. 登録日 2021-07-27 公開日 2021-11-03 最終更新日 2022-01-05 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat.Chem.Biol., 18, 2022
6WPW	GCGR-Gs signaling complex bound to a designed glucagon derivative 分子名称: Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Hilger, D, Krishna Kumar, K, Hu, H, Mathiesen, J.M, Skiniotis, G, Kobilka, B.K. 登録日 2020-04-28 公開日 2020-08-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into differences in G protein activation by family A and family B GPCRs. Science, 369, 2020
8H4K	GW9508-bound FFAR4 in complex with Gq 分子名称: 3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 He, Y, Yin, H. 登録日 2022-10-10 公開日 2023-06-21 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
7EZK	Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gs complex 分子名称: Chimera of Guanine nucleotide-binding protein G(i) subunit alpha-1 and Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Cholecystokinin receptor type A, Cholecystokinin-8, ... 著者 Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y. 登録日 2021-06-01 公開日 2021-08-25 最終更新日 2022-06-29 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor Nat.Chem.Biol., 17, 2021
8F76	Human olfactory receptor OR51E2 bound to propionate in complex with miniGs399 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Billesboelle, C.B, Manglik, A. 登録日 2022-11-18 公開日 2023-03-22 最終更新日 2023-04-05 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of odorant recognition by a human odorant receptor. Nature, 615, 2023
7RKX	Structure of US27-Gi-scFv16 in CL-state 分子名称: Antibody fragment scFv16, G-protein coupled receptor homolog US27, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Tsutsumi, N, Jude, K.M, Garcia, K.C. 登録日 2021-07-22 公開日 2022-01-26 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
7Y12	Cryo-EM structure of MrgD-Gi complex with beta-alanine 分子名称: BETA-ALANINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. 登録日 2022-06-06 公開日 2022-07-20 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
7XT8	Serotonin 4 (5-HT4) receptor-Gs-Nb35 complex 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. 登録日 2022-05-16 公開日 2022-07-27 最終更新日 2022-08-03 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
7XZ5	GPR119-Gs-LPC complex 分子名称: (4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, P, Huang, S, Jiang, Y, Xu, H.E. 登録日 2022-06-02 公開日 2022-08-24 最終更新日 2022-10-05 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nat.Struct.Mol.Biol., 29, 2022
7VGY	Melatonin receptor1-2-Iodomelatonin-Gicomplex 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, Q.G, Lu, Q.Y. 登録日 2021-09-20 公開日 2022-03-02 最終更新日 2022-09-14 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of the ligand binding and signaling mechanism of melatonin receptors. Nat Commun, 13, 2022
7F4I	Cryo-EM structure of SHU9119-bound melanocortin-1 receptor in complex with Gs protein and Nb35 分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. 登録日 2021-06-18 公開日 2021-09-08 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
7EW3	Cryo-EM structure of S1P-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein 分子名称: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhao, C, Wang, W, Wang, H.L, Shao, Z.H. 登録日 2021-05-24 公開日 2021-09-29 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32, 2022
7EW2	Cryo-EM structure of pFTY720-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein 分子名称: (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhao, C, Wang, W, Wang, H.L, Shao, Z.H. 登録日 2021-05-24 公開日 2021-09-29 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32, 2022
7F8W	Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gq 分子名称: Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. 登録日 2021-07-02 公開日 2021-10-13 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
7F55	Cryo-EM structure of bremelanotide-MC4R-Gs_Nb35 complex 分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. 登録日 2021-06-21 公開日 2021-11-03 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
7F58	Cryo-EM structure of THIQ-MC4R-Gs_Nb35 complex 分子名称: (3R)-N-[(2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxidanylidene-propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J. 登録日 2021-06-21 公開日 2021-11-03 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Res., 31, 2021
7D76	Cryo-EM structure of the beclomethasone-bound adhesion receptor GPR97-Go complex 分子名称: (8~{S},9~{R},10~{S},11~{S},13~{S},14~{S},16~{S},17~{R})-9-chloranyl-10,13,16-trimethyl-11,17-bis(oxidanyl)-17-(2-oxidanylethanoyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one, Adhesion G protein-coupled receptor G3; GPR97, CHOLESTEROL, ... 著者 Ping, Y, Mao, C, Xiao, P, Zhao, R, Jiang, Y, Yang, Z, An, W, Shen, D, Yang, F, Zhang, H, Qu, C, Shen, Q, Tian, C, Li, Z, Li, S, Wang, G, Tao, X, Wen, X, Zhong, Y, Yang, J, Yi, F, Yu, X, Xu, E, Zhang, Y, Sun, J. 登録日 2020-10-03 公開日 2021-02-03 最終更新日 2021-02-10 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structures of the glucocorticoid-bound adhesion receptor GPR97-G o complex. Nature, 589, 2021
5WG5	Human GRK2 in complex with Gbetagamma subunits and CCG224061 分子名称: 5-{[(3S,4R)-4-(4-fluorophenyl)piperidin-3-yl]methoxy}-2H-indazole, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Bouley, R, Tesmer, J.J.G. 登録日 2017-07-13 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors. Mol. Pharmacol., 92, 2017
7CKZ	Cryo-EM structure of Dopamine and LY3154207 bound dopamine receptor DRD1-Gs signaling complex 分子名称: 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ... 著者 Yan, W, Shao, Z. 登録日 2020-07-20 公開日 2021-03-03 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell, 184, 2021
7FIN	Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GIPR-Gs complex 分子名称: CHOLESTEROL, GAMMA-L-GLUTAMIC ACID, Gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor, ... 著者 Zhao, F.h, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. 登録日 2021-07-31 公開日 2022-02-23 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 2022

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