Human GRK2 in complex with Gbetagamma subunits and CCG224061

Summary for 5WG5

DescriptorBeta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywordsbeta-adrenergic receptor kinase 1 guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm  P25098
Cell membrane ; Lipid-anchor ; Cytoplasmic side  P63212
Total number of polymer chains3
Total molecular weight125304.33
Bouley, R.,Tesmer, J.J.G. (deposition date: 2017-07-13, release date: 2017-12-27)
Primary citation
Bouley, R.,Waldschmidt, H.V.,Cato, M.C.,Cannavo, A.,Song, J.,Cheung, J.Y.,Yao, X.Q.,Koch, W.J.,Larsen, S.D.,Tesmer, J.J.G.
Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol. Pharmacol., 92:707-717, 2017
PubMed: 29070696 (PDB entries with the same primary citation)
DOI: 10.1124/mol.117.110130
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2324 0.4% 0.6% 0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-28