5WG5
Human GRK2 in complex with Gbetagamma subunits and CCG224061
Summary for 5WG5
Entry DOI | 10.2210/pdb5wg5/pdb |
Descriptor | Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | beta-adrenergic receptor kinase 1 guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : P25098 Cell membrane ; Lipid-anchor ; Cytoplasmic side : P63212 |
Total number of polymer chains | 3 |
Total formula weight | 125304.33 |
Authors | Bouley, R.,Tesmer, J.J.G. (deposition date: 2017-07-13, release date: 2017-12-27, Last modification date: 2023-10-04) |
Primary citation | Bouley, R.,Waldschmidt, H.V.,Cato, M.C.,Cannavo, A.,Song, J.,Cheung, J.Y.,Yao, X.Q.,Koch, W.J.,Larsen, S.D.,Tesmer, J.J.G. Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors. Mol. Pharmacol., 92:707-717, 2017 Cited by PubMed: 29070696DOI: 10.1124/mol.117.110130 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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