PDB: 2602 件ウェブページステータス検索Chemie searchBIRD

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5XWR	Crystal Structure of RBBP4-peptide complex 分子名称: Histone-binding protein RBBP4, MET-SER-ARG-ARG-LYS-GLN-ALA-LYS-PRO-GLN-HIS-ILE 著者 Jobichen, C, Lui, B.H, Daniel, G.T, Sivaraman, J. 登録日 2017-06-30 公開日 2018-07-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4GQB	Crystal Structure of the human PRMT5:MEP50 Complex 分子名称: (2S,5S,6E)-2,5-diamino-6-[(3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxydihydrofuran-2(3H)-ylidene]hexanoic acid, Histone H4 peptide, Methylosome protein 50, ... 著者 Antonysamy, S, Bonday, Z, Campbell, R, Doyle, B, Druzina, Z, Gheyi, T, Han, B, Jungheim, L.N, Qian, Y, Rauch, C, Russell, M, Sauder, J.M, Wasserman, S.R, Weichert, K, Willard, F.S, Zhang, A, Emtage, S. 登録日 2012-08-22 公開日 2012-10-17 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Crystal structure of the human PRMT5:MEP50 complex. Proc.Natl.Acad.Sci.USA, 109, 2012
5WBL	Crystal structure of the Arabidopsis thaliana Raptor in complex with the TOS peptide of human PRAS40 分子名称: Proline-rich AKT1 substrate 1, Regulatory-associated protein of TOR 1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBU	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex 分子名称: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.42 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5M5G	Crystal structure of the Chaetomium Thermophilum polycomb repressive complex 2 (PRC2) 分子名称: Fragment from molecular 2 (region containing putative polycomb protein Suz12), HISTONE H3 11-Mer peptide, Putative uncharacterized protein, ... 著者 Zhang, Y, Justin, N, Wilson, J, Gamblin, S. 登録日 2016-10-21 公開日 2017-01-11 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2". Science, 354, 2016
5VTB	Crystal structure of RBBP4 bound to BCL11a peptide 分子名称: B-cell lymphoma/leukemia 11A, GLYCEROL, Histone-binding protein RBBP4 著者 Meagher, J.L, Stuckey, J.A. 登録日 2017-05-16 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes. J. Biol. Chem., 293, 2018
5WUK	Crystal structure of EED [G255D] in complex with EZH2 peptide and EED226 compound 分子名称: GLYCEROL, Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... 著者 Chen, Z. 登録日 2016-12-19 公開日 2017-05-03 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Split luciferase-based biosensors for characterizing EED binders Anal. Biochem., 522, 2017
5WAK	Crystal Structure of a Suz12-Rbbp4 Binary Complex 分子名称: Histone-binding protein RBBP4, Polycomb protein SUZ12, ZINC ION 著者 Chen, S, Jiao, L, Liu, X. 登録日 2017-06-26 公開日 2018-03-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Mol. Cell, 69, 2018
5WBK	Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human S6K1 分子名称: Regulatory-associated protein of TOR 1, Ribosomal protein S6 kinase beta-1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
4GGA	Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C 分子名称: Cell division cycle protein 20 homolog 著者 Luo, X, Tian, W, Tomchick, D.R. 登録日 2012-08-06 公開日 2012-11-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.044 Å) 主引用文献 Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. Proc.Natl.Acad.Sci.USA, 109, 2012
4GGC	Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, Cell division cycle protein 20 homolog 著者 Luo, X, Tian, W, Tomchick, D.R. 登録日 2012-08-06 公開日 2012-11-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. Proc.Natl.Acad.Sci.USA, 109, 2012
5WBJ	Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1 分子名称: Eukaryotic translation initiation factor 4E-binding protein 1, Regulatory-associated protein of TOR 1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBY	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(beta-strand) complex 分子名称: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5LS6	Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor 分子名称: 1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide, Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Jarid2 K116me3, ... 著者 Zhang, Y, Justin, N, Chen, S, Wilson, J, Gamblin, S. 登録日 2016-08-22 公開日 2017-02-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.47 Å) 主引用文献 Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas. J. Med. Chem., 59, 2016
5WJC	Crystal structure of Schizosaccharomyces pombe Mis16 in complex with Eic1 分子名称: Eic1 protein, Kinetochore protein Mis16 著者 An, S, Cho, U.-S, Koldewey, P, Chik, J, Subramanian, L. 登録日 2017-07-21 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.298 Å) 主引用文献 Mis16 Switches Function from a Histone H4 Chaperone to a CENP-ACnp1-Specific Assembly Factor through Eic1 Interaction. Structure, 26, 2018
4GQ2	S. pombe Nup120-Nup37 complex 分子名称: Nucleoporin nup120, Nup37 著者 Liu, X, Mitchell, J, Wozniak, R, Blobel, G, Fan, J. 登録日 2012-08-22 公開日 2012-10-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural evolution of the membrane-coating module of the nuclear pore complex. Proc.Natl.Acad.Sci.USA, 109, 2012
5WAI	Crystal Structure of a Suz12-Rbbp4-Jarid2-Aebp2 Heterotetrameric Complex 分子名称: Histone-binding protein RBBP4, Jumonji, AT-rich interactive domain 2, ... 著者 Chen, S, Jiao, L, Liu, X. 登録日 2017-06-26 公開日 2018-03-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Mol. Cell, 69, 2018
5WBI	Crystal structure of the Arabidopsis thaliana Raptor 分子名称: Regulatory-associated protein of TOR 1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5VK3	Apo ctPRC2 with E840A and K852D mutations in Ezh2 分子名称: Histone-lysine N-methyltransferase EZH2,Polycomb protein SUZ12, Polycomb Protein EED, ZINC ION 著者 Bratkowski, M.A, Liu, X. 登録日 2017-04-20 公開日 2017-06-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.114 Å) 主引用文献 Polycomb repressive complex 2 in an autoinhibited state. J. Biol. Chem., 292, 2017
5WG6	Human Polycomb Repressive Complex 2 in complex with GSK126 inhibitor 分子名称: 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide, Histone-lysine N-methyltransferase EZH2,Polycomb protein SUZ12 (E.C.2.1.1.43) chimera, Polycomb protein EED, ... 著者 Bratkowski, M.A, Liu, X. 登録日 2017-07-13 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.901 Å) 主引用文献 An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors. Sci Rep, 8, 2018
5LCW	Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic checkpoint complex (APC/C-MCC) at 4.2 angstrom resolution 分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... 著者 Alfieri, C, Chang, L, Zhang, Z, Yang, J, Maslen, S, Skehel, M, Barford, D. 登録日 2016-06-22 公開日 2016-08-10 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Molecular basis of APC/C regulation by the spindle assembly checkpoint. Nature, 536, 2016
5ZCS	4.9 Angstrom Cryo-EM structure of human mTOR complex 2 分子名称: Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... 著者 Chen, X, Liu, M, Tian, Y, Wang, H, Wang, J, Xu, Y. 登録日 2018-02-20 公開日 2018-03-21 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.9 Å) 主引用文献 Cryo-EM structure of human mTOR complex 2. Cell Res., 28, 2018
4JSN	structure of mTORdeltaN-mLST8 complex 分子名称: Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JT6	structure of mTORDeltaN-mLST8-PI-103 complex 分子名称: 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL, mLST8, mTOR 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JSV	mTOR kinase structure, mechanism and regulation. 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase mTOR, ... 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013

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