5WG6
Human Polycomb Repressive Complex 2 in complex with GSK126 inhibitor
Summary for 5WG6
| Entry DOI | 10.2210/pdb5wg6/pdb |
| Related | 5WF7 5WFC 5WFD |
| Descriptor | Histone-lysine N-methyltransferase EZH2,Polycomb protein SUZ12 (E.C.2.1.1.43) chimera, Polycomb protein EED, ZINC ION, ... (4 entities in total) |
| Functional Keywords | complex, epigenetics, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 300593.79 |
| Authors | Bratkowski, M.A.,Liu, X. (deposition date: 2017-07-13, release date: 2018-06-27, Last modification date: 2023-10-04) |
| Primary citation | Bratkowski, M.,Yang, X.,Liu, X. An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors. Sci Rep, 8:9092-9092, 2018 Cited by PubMed: 29904056DOI: 10.1038/s41598-018-27175-w PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.901 Å) |
Structure validation
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