5WG6

Human Polycomb Repressive Complex 2 in complex with GSK126 inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0000792	cellular_component	heterochromatin
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
A	0001222	molecular_function	transcription corepressor binding
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003714	molecular_function	transcription corepressor activity
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005677	cellular_component	chromatin silencing complex
A	0005694	cellular_component	chromosome
A	0005721	cellular_component	pericentric heterochromatin
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008168	molecular_function	methyltransferase activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0030183	biological_process	B cell differentiation
A	0030335	biological_process	positive regulation of cell migration
A	0031048	biological_process	regulatory ncRNA-mediated heterochromatin formation
A	0031490	molecular_function	chromatin DNA binding
A	0031491	molecular_function	nucleosome binding
A	0031507	biological_process	heterochromatin formation
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0031519	cellular_component	PcG protein complex
A	0032259	biological_process	methylation
A	0035098	cellular_component	ESC/E(Z) complex
A	0042054	molecular_function	histone methyltransferase activity
A	0042393	molecular_function	histone binding
A	0042752	biological_process	regulation of circadian rhythm
A	0043021	molecular_function	ribonucleoprotein complex binding
A	0043406	biological_process	positive regulation of MAP kinase activity
A	0043547	biological_process	positive regulation of GTPase activity
A	0043565	molecular_function	sequence-specific DNA binding
A	0045120	cellular_component	pronucleus
A	0045814	biological_process	negative regulation of gene expression, epigenetic
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046976	molecular_function	histone H3K27 methyltransferase activity
A	0048387	biological_process	negative regulation of retinoic acid receptor signaling pathway
A	0048468	biological_process	cell development
A	0048511	biological_process	rhythmic process
A	0070878	molecular_function	primary miRNA binding
A	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
A	0106222	molecular_function	lncRNA binding
A	0140718	biological_process	facultative heterochromatin formation
A	0140938	molecular_function	histone H3 methyltransferase activity
A	0140951	molecular_function	histone H3K27 trimethyltransferase activity
A	1902808	biological_process	positive regulation of cell cycle G1/S phase transition
A	1990841	molecular_function	promoter-specific chromatin binding
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0001222	molecular_function	transcription corepressor binding
B	0001739	cellular_component	sex chromatin
B	0003682	molecular_function	chromatin binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005677	cellular_component	chromatin silencing complex
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
B	0008047	molecular_function	enzyme activator activity
B	0021510	biological_process	spinal cord development
B	0031491	molecular_function	nucleosome binding
B	0031507	biological_process	heterochromatin formation
B	0035098	cellular_component	ESC/E(Z) complex
B	0042802	molecular_function	identical protein binding
B	0045120	cellular_component	pronucleus
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0140718	biological_process	facultative heterochromatin formation
B	1990841	molecular_function	promoter-specific chromatin binding
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0000792	cellular_component	heterochromatin
C	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
C	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
C	0001222	molecular_function	transcription corepressor binding
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0003714	molecular_function	transcription corepressor activity
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005677	cellular_component	chromatin silencing complex
C	0005694	cellular_component	chromosome
C	0005721	cellular_component	pericentric heterochromatin
C	0006325	biological_process	chromatin organization
C	0006338	biological_process	chromatin remodeling
C	0006355	biological_process	regulation of DNA-templated transcription
C	0008168	molecular_function	methyltransferase activity
C	0008284	biological_process	positive regulation of cell population proliferation
C	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
C	0016279	molecular_function	protein-lysine N-methyltransferase activity
C	0016740	molecular_function	transferase activity
C	0030183	biological_process	B cell differentiation
C	0030335	biological_process	positive regulation of cell migration
C	0031048	biological_process	regulatory ncRNA-mediated heterochromatin formation
C	0031490	molecular_function	chromatin DNA binding
C	0031491	molecular_function	nucleosome binding
C	0031507	biological_process	heterochromatin formation
C	0031509	biological_process	subtelomeric heterochromatin formation
C	0031519	cellular_component	PcG protein complex
C	0032259	biological_process	methylation
C	0035098	cellular_component	ESC/E(Z) complex
C	0042054	molecular_function	histone methyltransferase activity
C	0042393	molecular_function	histone binding
C	0042752	biological_process	regulation of circadian rhythm
C	0043021	molecular_function	ribonucleoprotein complex binding
C	0043406	biological_process	positive regulation of MAP kinase activity
C	0043547	biological_process	positive regulation of GTPase activity
C	0043565	molecular_function	sequence-specific DNA binding
C	0045120	cellular_component	pronucleus
C	0045814	biological_process	negative regulation of gene expression, epigenetic
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0046976	molecular_function	histone H3K27 methyltransferase activity
C	0048387	biological_process	negative regulation of retinoic acid receptor signaling pathway
C	0048468	biological_process	cell development
C	0048511	biological_process	rhythmic process
C	0070878	molecular_function	primary miRNA binding
C	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
C	0106222	molecular_function	lncRNA binding
C	0140718	biological_process	facultative heterochromatin formation
C	0140938	molecular_function	histone H3 methyltransferase activity
C	0140951	molecular_function	histone H3K27 trimethyltransferase activity
C	1902808	biological_process	positive regulation of cell cycle G1/S phase transition
C	1990841	molecular_function	promoter-specific chromatin binding
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0001222	molecular_function	transcription corepressor binding
D	0001739	cellular_component	sex chromatin
D	0003682	molecular_function	chromatin binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005677	cellular_component	chromatin silencing complex
D	0005694	cellular_component	chromosome
D	0006325	biological_process	chromatin organization
D	0008047	molecular_function	enzyme activator activity
D	0021510	biological_process	spinal cord development
D	0031491	molecular_function	nucleosome binding
D	0031507	biological_process	heterochromatin formation
D	0035098	cellular_component	ESC/E(Z) complex
D	0042802	molecular_function	identical protein binding
D	0045120	cellular_component	pronucleus
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0140718	biological_process	facultative heterochromatin formation
D	1990841	molecular_function	promoter-specific chromatin binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue ZN A 9001

Chain	Residue
A	CYS452
A	CYS463

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 9002

Chain	Residue
A	CYS530
A	CYS543
A	CYS549
A	CYS553

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 9003

Chain	Residue
A	CYS547
A	CYS523
A	CYS536
A	CYS543

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 9004

Chain	Residue
A	CYS523
A	HIS525
A	CYS530
A	CYS534

---

site_id	AC5
Number of Residues	5
Details	binding site for residue ZN A 9005

Chain	Residue
A	CYS560
A	CYS573
A	CYS580
A	CYS585
A	ZN9006

---

site_id	AC6
Number of Residues	5
Details	binding site for residue ZN A 9006

Chain	Residue
A	CYS566
A	CYS580
A	CYS588
A	CYS601
A	ZN9005

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN A 9007

Chain	Residue
A	CYS560
A	CYS562
A	CYS566
A	CYS571

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN A 9008

Chain	Residue
A	CYS286
A	CYS289
A	CYS294
A	HIS297

---

site_id	AC9
Number of Residues	10
Details	binding site for residue A9G A 9009

Chain	Residue
A	ILE109
A	TYR111
A	TRP624
A	TYR661
A	CYS663
A	PHE665
A	THR678
A	ARG685
A	PHE686
A	ASN688

---

site_id	AD1
Number of Residues	1
Details	binding site for residue ZN C 9001

Chain	Residue
C	CYS452

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN C 9002

Chain	Residue
C	CYS530
C	CYS543
C	CYS549
C	CYS553

---

site_id	AD3
Number of Residues	5
Details	binding site for residue ZN C 9003

Chain	Residue
C	CYS523
C	CYS536
C	CYS543
C	CYS547
C	ZN9004

---

site_id	AD4
Number of Residues	5
Details	binding site for residue ZN C 9004

Chain	Residue
C	CYS523
C	HIS525
C	CYS530
C	CYS534
C	ZN9003

---

site_id	AD5
Number of Residues	6
Details	binding site for residue ZN C 9005

Chain	Residue
C	CYS560
C	CYS573
C	CYS580
C	CYS585
C	ZN9006
C	ZN9007

---

site_id	AD6
Number of Residues	6
Details	binding site for residue ZN C 9006

Chain	Residue
C	CYS566
C	CYS580
C	CYS588
C	CYS601
C	ZN9005
C	ZN9007

---

site_id	AD7
Number of Residues	6
Details	binding site for residue ZN C 9007

Chain	Residue
C	CYS560
C	CYS562
C	CYS566
C	CYS571
C	ZN9005
C	ZN9006

---

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN C 9008

Chain	Residue
C	CYS286
C	CYS289
C	CYS294
C	HIS297

---

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI

Chain	Residue	Details
B	LEU206-ILE220

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	Region: {"description":"VEFS-box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	230
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	29
Details	Region: {"description":"Interaction with EED","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	43
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	86
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	80
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	82
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	37
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	308
Details	Region: {"description":"Required for interaction with the matrix protein MA of HIV-1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"20974918","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---