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5WG6

Human Polycomb Repressive Complex 2 in complex with GSK126 inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0000976molecular_functiontranscription cis-regulatory region binding
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
A0001222molecular_functiontranscription corepressor binding
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0003714molecular_functiontranscription corepressor activity
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005677cellular_componentchromatin silencing complex
A0005694cellular_componentchromosome
A0005721cellular_componentpericentric heterochromatin
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0006346biological_processDNA methylation-dependent heterochromatin formation
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0008168molecular_functionmethyltransferase activity
A0008284biological_processpositive regulation of cell population proliferation
A0009913biological_processepidermal cell differentiation
A0010468biological_processregulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0014013biological_processregulation of gliogenesis
A0014834biological_processskeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
A0014898biological_processcardiac muscle hypertrophy in response to stress
A0016279molecular_functionprotein-lysine N-methyltransferase activity
A0021695biological_processcerebellar cortex development
A0021766biological_processhippocampus development
A0030097biological_processhemopoiesis
A0030183biological_processB cell differentiation
A0030216biological_processkeratinocyte differentiation
A0030335biological_processpositive regulation of cell migration
A0031048biological_processregulatory ncRNA-mediated heterochromatin formation
A0031490molecular_functionchromatin DNA binding
A0031491molecular_functionnucleosome binding
A0031507biological_processheterochromatin formation
A0031509biological_processsubtelomeric heterochromatin formation
A0032259biological_processmethylation
A0032355biological_processresponse to estradiol
A0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
A0035098cellular_componentESC/E(Z) complex
A0035984biological_processcellular response to trichostatin A
A0036211biological_processprotein modification process
A0036333biological_processhepatocyte homeostasis
A0042054molecular_functionhistone methyltransferase activity
A0042127biological_processregulation of cell population proliferation
A0042393molecular_functionhistone binding
A0042752biological_processregulation of circadian rhythm
A0043021molecular_functionribonucleoprotein complex binding
A0043406biological_processpositive regulation of MAP kinase activity
A0043547biological_processpositive regulation of GTPase activity
A0043565molecular_functionsequence-specific DNA binding
A0045120cellular_componentpronucleus
A0045202cellular_componentsynapse
A0045605biological_processnegative regulation of epidermal cell differentiation
A0045617biological_processnegative regulation of keratinocyte differentiation
A0045814biological_processnegative regulation of gene expression, epigenetic
A0045892biological_processnegative regulation of DNA-templated transcription
A0046976molecular_functionhistone H3K27 methyltransferase activity
A0048387biological_processnegative regulation of retinoic acid receptor signaling pathway
A0048511biological_processrhythmic process
A0048863biological_processstem cell differentiation
A0050767biological_processregulation of neurogenesis
A0051154biological_processnegative regulation of striated muscle cell differentiation
A0051932biological_processsynaptic transmission, GABAergic
A0070301biological_processcellular response to hydrogen peroxide
A0070314biological_processG1 to G0 transition
A0070878molecular_functionprimary miRNA binding
A0071168biological_processprotein localization to chromatin
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0090183biological_processregulation of kidney development
A0097421biological_processliver regeneration
A0106222molecular_functionlncRNA binding
A0140718biological_processfacultative heterochromatin formation
A0140938molecular_functionhistone H3 methyltransferase activity
A0140951molecular_functionhistone H3K27 trimethyltransferase activity
A1900006biological_processpositive regulation of dendrite development
A1900016biological_processnegative regulation of cytokine production involved in inflammatory response
A1902808biological_processpositive regulation of cell cycle G1/S phase transition
A1904772biological_processresponse to tetrachloromethane
A1990841molecular_functionpromoter-specific chromatin binding
A2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
A2000737biological_processnegative regulation of stem cell differentiation
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001222molecular_functiontranscription corepressor binding
B0003682molecular_functionchromatin binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005829cellular_componentcytosol
B0006325biological_processchromatin organization
B0008047molecular_functionenzyme activator activity
B0021510biological_processspinal cord development
B0031491molecular_functionnucleosome binding
B0031507biological_processheterochromatin formation
B0035098cellular_componentESC/E(Z) complex
B0042802molecular_functionidentical protein binding
B0045892biological_processnegative regulation of DNA-templated transcription
C0000082biological_processG1/S transition of mitotic cell cycle
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000781cellular_componentchromosome, telomeric region
C0000785cellular_componentchromatin
C0000976molecular_functiontranscription cis-regulatory region binding
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
C0001222molecular_functiontranscription corepressor binding
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0003714molecular_functiontranscription corepressor activity
C0003723molecular_functionRNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005677cellular_componentchromatin silencing complex
C0005694cellular_componentchromosome
C0005721cellular_componentpericentric heterochromatin
C0006325biological_processchromatin organization
C0006338biological_processchromatin remodeling
C0006346biological_processDNA methylation-dependent heterochromatin formation
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0008168molecular_functionmethyltransferase activity
C0008284biological_processpositive regulation of cell population proliferation
C0009913biological_processepidermal cell differentiation
C0010468biological_processregulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0010718biological_processpositive regulation of epithelial to mesenchymal transition
C0014013biological_processregulation of gliogenesis
C0014834biological_processskeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
C0014898biological_processcardiac muscle hypertrophy in response to stress
C0016279molecular_functionprotein-lysine N-methyltransferase activity
C0021695biological_processcerebellar cortex development
C0021766biological_processhippocampus development
C0030097biological_processhemopoiesis
C0030183biological_processB cell differentiation
C0030216biological_processkeratinocyte differentiation
C0030335biological_processpositive regulation of cell migration
C0031048biological_processregulatory ncRNA-mediated heterochromatin formation
C0031490molecular_functionchromatin DNA binding
C0031491molecular_functionnucleosome binding
C0031507biological_processheterochromatin formation
C0031509biological_processsubtelomeric heterochromatin formation
C0032259biological_processmethylation
C0032355biological_processresponse to estradiol
C0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
C0035098cellular_componentESC/E(Z) complex
C0035984biological_processcellular response to trichostatin A
C0036211biological_processprotein modification process
C0036333biological_processhepatocyte homeostasis
C0042054molecular_functionhistone methyltransferase activity
C0042127biological_processregulation of cell population proliferation
C0042393molecular_functionhistone binding
C0042752biological_processregulation of circadian rhythm
C0043021molecular_functionribonucleoprotein complex binding
C0043406biological_processpositive regulation of MAP kinase activity
C0043547biological_processpositive regulation of GTPase activity
C0043565molecular_functionsequence-specific DNA binding
C0045120cellular_componentpronucleus
C0045202cellular_componentsynapse
C0045605biological_processnegative regulation of epidermal cell differentiation
C0045617biological_processnegative regulation of keratinocyte differentiation
C0045814biological_processnegative regulation of gene expression, epigenetic
C0045892biological_processnegative regulation of DNA-templated transcription
C0046976molecular_functionhistone H3K27 methyltransferase activity
C0048387biological_processnegative regulation of retinoic acid receptor signaling pathway
C0048511biological_processrhythmic process
C0048863biological_processstem cell differentiation
C0050767biological_processregulation of neurogenesis
C0051154biological_processnegative regulation of striated muscle cell differentiation
C0051932biological_processsynaptic transmission, GABAergic
C0070301biological_processcellular response to hydrogen peroxide
C0070314biological_processG1 to G0 transition
C0070878molecular_functionprimary miRNA binding
C0071168biological_processprotein localization to chromatin
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0090183biological_processregulation of kidney development
C0097421biological_processliver regeneration
C0106222molecular_functionlncRNA binding
C0140718biological_processfacultative heterochromatin formation
C0140938molecular_functionhistone H3 methyltransferase activity
C0140951molecular_functionhistone H3K27 trimethyltransferase activity
C1900006biological_processpositive regulation of dendrite development
C1900016biological_processnegative regulation of cytokine production involved in inflammatory response
C1902808biological_processpositive regulation of cell cycle G1/S phase transition
C1904772biological_processresponse to tetrachloromethane
C1990841molecular_functionpromoter-specific chromatin binding
C2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
C2000737biological_processnegative regulation of stem cell differentiation
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0001222molecular_functiontranscription corepressor binding
D0003682molecular_functionchromatin binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0005829cellular_componentcytosol
D0006325biological_processchromatin organization
D0008047molecular_functionenzyme activator activity
D0021510biological_processspinal cord development
D0031491molecular_functionnucleosome binding
D0031507biological_processheterochromatin formation
D0035098cellular_componentESC/E(Z) complex
D0042802molecular_functionidentical protein binding
D0045892biological_processnegative regulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue ZN A 9001
ChainResidue
ACYS452
ACYS463

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN A 9002
ChainResidue
ACYS530
ACYS543
ACYS549
ACYS553

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN A 9003
ChainResidue
ACYS547
ACYS523
ACYS536
ACYS543

site_idAC4
Number of Residues4
Detailsbinding site for residue ZN A 9004
ChainResidue
ACYS523
AHIS525
ACYS530
ACYS534

site_idAC5
Number of Residues5
Detailsbinding site for residue ZN A 9005
ChainResidue
ACYS560
ACYS573
ACYS580
ACYS585
AZN9006

site_idAC6
Number of Residues5
Detailsbinding site for residue ZN A 9006
ChainResidue
ACYS566
ACYS580
ACYS588
ACYS601
AZN9005

site_idAC7
Number of Residues4
Detailsbinding site for residue ZN A 9007
ChainResidue
ACYS560
ACYS562
ACYS566
ACYS571

site_idAC8
Number of Residues4
Detailsbinding site for residue ZN A 9008
ChainResidue
ACYS286
ACYS289
ACYS294
AHIS297

site_idAC9
Number of Residues10
Detailsbinding site for residue A9G A 9009
ChainResidue
AILE109
ATYR111
ATRP624
ATYR661
ACYS663
APHE665
ATHR678
AARG685
APHE686
AASN688

site_idAD1
Number of Residues1
Detailsbinding site for residue ZN C 9001
ChainResidue
CCYS452

site_idAD2
Number of Residues4
Detailsbinding site for residue ZN C 9002
ChainResidue
CCYS530
CCYS543
CCYS549
CCYS553

site_idAD3
Number of Residues5
Detailsbinding site for residue ZN C 9003
ChainResidue
CCYS523
CCYS536
CCYS543
CCYS547
CZN9004

site_idAD4
Number of Residues5
Detailsbinding site for residue ZN C 9004
ChainResidue
CCYS523
CHIS525
CCYS530
CCYS534
CZN9003

site_idAD5
Number of Residues6
Detailsbinding site for residue ZN C 9005
ChainResidue
CCYS560
CCYS573
CCYS580
CCYS585
CZN9006
CZN9007

site_idAD6
Number of Residues6
Detailsbinding site for residue ZN C 9006
ChainResidue
CCYS566
CCYS580
CCYS588
CCYS601
CZN9005
CZN9007

site_idAD7
Number of Residues6
Detailsbinding site for residue ZN C 9007
ChainResidue
CCYS560
CCYS562
CCYS566
CCYS571
CZN9005
CZN9006

site_idAD8
Number of Residues4
Detailsbinding site for residue ZN C 9008
ChainResidue
CCYS286
CCYS289
CCYS294
CHIS297

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI
ChainResidueDetails
BLEU206-ILE220

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER2
DSER2

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q921E6
ChainResidueDetails
BSER34
DSER34
CSER76
CSER398

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
BTHR55
DTHR55

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:20974918
ChainResidueDetails
BLYS66
BLYS197
BLYS268
BLYS284
DLYS66
DLYS197
DLYS268
DLYS284

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER401
CSER401

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR402
CTHR402

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR487
CTHR487

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:24474760
ChainResidueDetails
ASER75
CSER75

site_idSWS_FT_FI9
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS634
CLYS634

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER2546
CSER2546

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336
ChainResidueDetails
ASER2583
CSER2583

225946

PDB entries from 2024-10-09

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