5WG6

Human Polycomb Repressive Complex 2 in complex with GSK126 inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Histone-lysine N-methyltransferase EZH2,Polycomb protein SUZ12 (E.C.2.1.1.43) chimera	polymer	859	99155.5	2	UniProt (Q15910) UniProt (Q15022) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) Pfam (PF09733) In PDB	Homo sapiens (Human)	ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6
2	B, D	Polycomb protein EED	polymer	442	50354.8	2	UniProt (O75530) Pfam (PF00400) In PDB	Homo sapiens (Human)	hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1
3	A, C	ZINC ION	non-polymer		65.4	16	Chemie (ZN)
4	A	1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide	non-polymer		526.7	1	Chemie (A9G)

Sequence modifications

A, C: 2 - 195 (UniProt: Q15910)

PDB	External Database	Details
Ser -7	-	expression tag
Asn -6	-	expression tag
Ala -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag

A, C: 196 - 420 (UniProt: Q15910)
A, C: 421 - 2542 (UniProt: Q15910)

PDB	External Database	Details
Arg 594	Trp 594	see remark 999

A, C: 2543 - 2695 (UniProt: Q15022)
B, D: 2 - 441 (UniProt: O75530)

PDB	External Database	Details
Met 0	-	initiating methionine
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	299020.6
Non-Polymers*	Number of molecules	17
	Total formula weight	1573.2
All*	Total formula weight	300593.8

*Water molecules are not included.