5WUK

Crystal structure of EED [G255D] in complex with EZH2 peptide and EED226 compound

Summary for 5WUK

Entry DOI	10.2210/pdb5wuk/pdb
Descriptor	Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, GLYCEROL, ... (5 entities in total)
Functional Keywords	eed, gene regulation
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus: O75530 Q15910
Total number of polymer chains	2
Total formula weight	46353.81
Authors	Chen, Z. (deposition date: 2016-12-19, release date: 2017-05-03)
Primary citation	Li, L.,Feng, L.,Shi, M.,Zeng, J.,Chen, Z.,Zhong, L.,Huang, L.,Guo, W.,Huang, Y.,Qi, W.,Lu, C.,Li, E.,Zhao, K.,Gu, J. Split luciferase-based biosensors for characterizing EED binders Anal. Biochem., 522:37-45, 2017 Cited by PubMed: 28111304 DOI: 10.1016/j.ab.2017.01.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation