5WUK
Crystal structure of EED [G255D] in complex with EZH2 peptide and EED226 compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polycomb protein EED | polymer | 366 | 42357.2 | 1 | UniProt (O75530) Pfam (PF00400) | Homo sapiens (Human) | hEED,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 2 | B (B) | Histone-lysine N-methyltransferase EZH2 | polymer | 28 | 3535.1 | 1 | UniProt (Q15910) Pfam (PF11616) | Homo sapiens | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (A) | N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | non-polymer | 369.4 | 1 | Chemie (73K) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 340 | Chemie (HOH) |
Sequence modifications
A: 76 - 441 (UniProt: O75530)
| PDB | External Database | Details |
|---|---|---|
| Asp 255 | Gly 255 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 45892.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 461.5 | |
| All* | Total formula weight | 46353.8 |
