PDB: 688 件ウェブページステータス検索Chemie searchBIRD

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3PD9	X-ray structure of the ligand-binding core of GluA2 in complex with (R)-5-HPCA at 2.1 A resolution 分子名称: (5R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid, CHLORIDE ION, GLYCEROL, ... 著者 Frydenvang, K, Kastrup, J.S. 登録日 2010-10-22 公開日 2010-12-29 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. J. Med. Chem., 53, 2010
3RTF	Chlorowillardiine bound to the ligand binding domain of GluA2 分子名称: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-05-03 公開日 2011-05-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3R7X	Crystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity 分子名称: GLUTAMIC ACID, Glutamate receptor 2, N-[6-(1H-imidazol-1-yl)-7-nitro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methanesulfonamide 著者 Kallen, J. 登録日 2011-03-23 公開日 2011-05-18 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Quinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity. Bioorg.Med.Chem.Lett., 21, 2011
3RNN	Crystal Structure of iGluR2 Ligand Binding Domain with Symmetric Sulfonamide Containing Potentiator 分子名称: GLUTAMIC ACID, Glutamate receptor 2, N,N'-(benzene-1,4-diyldiethane-2,1-diyl)dipropane-2-sulfonamide, ... 著者 Timm, D.E. 登録日 2011-04-22 公開日 2011-05-25 最終更新日 2019-07-17 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
3RT6	Fluorowillardiine bound to the ligand binding domain of GluA3 分子名称: 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-05-03 公開日 2011-05-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.836 Å) 主引用文献 Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3RT8	Chlorowillardiine bound to the ligand binding domain of GluA3 分子名称: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 3, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-05-03 公開日 2011-05-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.426 Å) 主引用文献 Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
5FXK	GluN1b-GluN2B NMDA receptor structure-Class Y 分子名称: N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B 著者 Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. 登録日 2016-03-02 公開日 2016-05-11 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (6.4 Å) 主引用文献 Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
5FTH	Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (zinc form) 分子名称: GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ZINC ION 著者 Nayeem, N, Green, T. 登録日 2016-01-13 公開日 2016-02-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Distinct Structural Pathways Coordinate the Activation of Ampa Receptor-Auxiliary Subunit Complexes. Neuron, 89, 2016
5FHM	Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-(aminomethyl)benzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at resolution 1.55 A resolution 分子名称: (2~{S})-3-[5-[2-[[3-(aminomethyl)phenyl]methyl]-1,2,3,4-tetrazol-5-yl]-3-oxidanyl-1,2-oxazol-4-yl]-2-azanyl-propanoic acid, 1,2-ETHANEDIOL, ACETATE ION, ... 著者 Kastrup, J.S, Frydenvang, K, Al-musaed, A. 登録日 2015-12-22 公開日 2016-03-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues. J.Med.Chem., 59, 2016
5FXH	GluN1b-GluN2B NMDA receptor in non-active-1 conformation 分子名称: N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B 著者 Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. 登録日 2016-03-02 公開日 2016-05-11 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (5 Å) 主引用文献 Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
5FHN	Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-methylbenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 1.6 A resolution 分子名称: (S)-2-Amino-3-(5-(2-(3-methylbenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid, 1,2-ETHANEDIOL, ACETATE ION, ... 著者 Frydenvang, K, Kastrup, J.S. 登録日 2015-12-22 公開日 2016-03-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues. J.Med.Chem., 59, 2016
5H8N	Structure of the human GluN1/GluN2A LBD in complex with NAM 分子名称: 4-[[(4-fluorophenyl)sulfonylamino]methyl]-~{N}-(pyridin-3-ylmethyl)benzamide, CALCIUM ION, GLUTAMIC ACID, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2015-12-23 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5FXG	GLUN1B-GLUN2B NMDA RECEPTOR IN ACTIVE CONFORMATION 分子名称: N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B 著者 Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. 登録日 2016-03-02 公開日 2016-05-11 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (6.8 Å) 主引用文献 Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
5H8H	Structure of the human GluN1/GluN2A LBD in complex with GNE3419 分子名称: 7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, ACETATE ION, CALCIUM ION, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2015-12-23 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5FXI	GluN1b-GluN2B NMDA receptor structure in non-active-2 conformation 分子名称: N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B 著者 Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H. 登録日 2016-03-02 公開日 2016-05-11 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (6.4 Å) 主引用文献 Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
5FHO	Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-chlorobenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 2.3 A resolution 分子名称: (1S)-1-carboxy-2-(5-{2-[(3-chlorophenyl)methyl]-2H-tetrazol-5-yl}-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)ethan-1-aminium, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Frydenvang, K, Kastrup, J.S. 登録日 2015-12-22 公開日 2016-03-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues. J.Med.Chem., 59, 2016
5FTI	Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (lithium form) 分子名称: GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, GLYCEROL, ... 著者 Nayeem, N, Green, T. 登録日 2016-01-13 公開日 2016-02-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Distinct Structural Pathways Coordinate the Activation of Ampa Receptor-Auxiliary Subunit Complexes. Neuron, 89, 2016
5I59	Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains with MPX 007 分子名称: 5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-4H-1lambda~4~,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide, GLUTAMIC ACID, GLYCINE, ... 著者 Mou, T.-C, Sprang, S.R, Hansen, K.B. 登録日 2016-02-14 公開日 2016-09-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors. Neuron, 91, 2016
5FXJ	GluN1b-GluN2B NMDA receptor structure-Class X 分子名称: GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1, NMDA 2B 著者 Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa H, H. 登録日 2016-03-02 公開日 2016-05-25 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (6.25 Å) 主引用文献 Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil. Nature, 534, 2016
5H8F	Structure of the apo human GluN1/GluN2A LBD 分子名称: GLUTAMIC ACID, GLYCEROL, GLYCINE, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2015-12-23 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5H8S	Structure of the human GluA2 LBD in complex with GNE3419 分子名称: 7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, CACODYLATE ION, GLUTAMIC ACID, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2015-12-23 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.703 Å) 主引用文献 Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5H8Q	Structure of the human GluN1/GluN2A LBD in complex with GNE8324 分子名称: 6-[[ethyl-(4-fluorophenyl)amino]methyl]-2,3-dihydro-1~{H}-cyclopenta[3,4][1,3]thiazolo[1,4-~{a}]pyrimidin-8-one, ACETATE ION, GLUTAMIC ACID, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2015-12-23 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron, 89, 2016
5IOU	Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine-bound conformation 分子名称: GLUTAMIC ACID, GLYCINE, Ionotropic glutamate receptor subunit NR2B, ... 著者 Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. 登録日 2016-03-09 公開日 2016-04-20 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (7 Å) 主引用文献 Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
5IPU	Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 6 分子名称: Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a 著者 Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. 登録日 2016-03-09 公開日 2016-04-20 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (15.4 Å) 主引用文献 Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
5I2K	Structure of the human GluN1/GluN2A LBD in complex with 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide (compound 19) 分子名称: 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide, GLUTAMIC ACID, GLYCINE, ... 著者 Wallweber, H.J.A, Lupardus, P.J. 登録日 2016-02-09 公開日 2016-03-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design. J.Med.Chem., 59, 2016

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