5FHO

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-chlorobenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 2.3 A resolution

Summary for 5FHO

• Entry DOI: 10.2210/pdb5fho/pdb
• Related: 2P2A
• Descriptor: Glutamate receptor 2,Glutamate receptor 2, (1S)-1-carboxy-2-(5-{2-[(3-chlorophenyl)methyl]-2H-tetrazol-5-yl}-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)ethan-1-aminium, SULFATE ION, ... (8 entities in total)
• Functional Keywords: ionotropic glutamate receptor glua2, ligand-binding domain, membrane protein, signaling protein
• Biological source: Rattus norvegicus (Norway Rat); More
• Cellular location: Cell membrane ; Multi-pass membrane protein : P19491
• Total number of polymer chains: 4
• Total formula weight: 121665.51

Authors

Frydenvang, K.,Kastrup, J.S. (deposition date: 2015-12-22, release date: 2016-03-02, Last modification date: 2024-01-10)

• Primary citation: Wang, S.Y.,Larsen, Y.,Navarrete, C.V.,Jensen, A.A.,Nielsen, B.,Al-Musaed, A.,Frydenvang, K.,Kastrup, J.S.,Pickering, D.S.,Clausen, R.P.; Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues.; J.Med.Chem., 59:2244-2254, 2016; PubMed: 26862980; DOI: 10.1021/acs.jmedchem.5b01982

Experimental method

X-RAY DIFFRACTION (2.3 Å)