5FHO

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-chlorobenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 2.3 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue 5XN A 301

Chain	Residue
A	GLU13
A	SER142
A	THR143
A	LEU192
A	GLU193
A	THR195
A	MET196
A	TYR220
A	HOH415
A	SER14
A	TYR16
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141

---

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 302

Chain	Residue
A	LYS204
A	HOH418
B	ARG64

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 303

Chain	Residue
A	ARG64
A	ALA66
A	ARG148
A	ARG149
A	HOH451
A	HOH454

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 304

Chain	Residue
A	LEU94
A	GLU98
A	ARG149
D	LYS240

---

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 305

Chain	Residue
A	HIS46
A	LYS240
A	GLN244

---

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL A 306

Chain	Residue
A	ASN242
A	GLU243
A	GLY245
A	ASP248
D	LEU215
D	ASP216
D	SER217

---

site_id	AC7
Number of Residues	1
Details	binding site for residue CL A 307

Chain	Residue
A	THR5

---

site_id	AC8
Number of Residues	1
Details	binding site for residue CL A 308

Chain	Residue
A	SER108

---

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO A 309

Chain	Residue
A	ASP58
A	LYS60
A	ARG172

---

site_id	AD1
Number of Residues	2
Details	binding site for residue EDO A 310

Chain	Residue
A	THR173
A	GLU176

---

site_id	AD2
Number of Residues	4
Details	binding site for residue EDO A 311

Chain	Residue
A	SER168
A	PHE170
A	ARG172
A	GLU176

---

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO A 312

Chain	Residue
A	ILE92
A	LYS218
A	GLY219
D	LYS104
D	PRO105

---

site_id	AD4
Number of Residues	2
Details	binding site for residue EDO A 313

Chain	Residue
A	ASN29
A	TYR51

---

site_id	AD5
Number of Residues	17
Details	binding site for residue 5XN B 301

Chain	Residue
B	GLU13
B	SER14
B	TYR16
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	LEU192
B	GLU193
B	THR195
B	MET196
B	TYR220
B	HOH413

---

site_id	AD6
Number of Residues	3
Details	binding site for residue SO4 B 302

Chain	Residue
B	ARG163
B	LYS204
B	HOH411

---

site_id	AD7
Number of Residues	2
Details	binding site for residue SO4 B 303

Chain	Residue
B	ARG149
C	LYS240

---

site_id	AD8
Number of Residues	2
Details	binding site for residue SO4 B 304

Chain	Residue
B	ARG148
B	HOH408

---

site_id	AD9
Number of Residues	4
Details	binding site for residue SO4 B 305

Chain	Residue
B	HIS46
B	LYS240
B	GLN244
C	LYS151

---

site_id	AE1
Number of Residues	4
Details	binding site for residue GOL B 306

Chain	Residue
B	LYS151
B	ALA153
C	LYS249
D	LYS4

---

site_id	AE2
Number of Residues	3
Details	binding site for residue GOL B 307

Chain	Residue
B	LYS69
B	TYR80
B	HOH478

---

site_id	AE3
Number of Residues	5
Details	binding site for residue PG4 B 308

Chain	Residue
B	ARG148
B	TRP159
B	THR160
B	ARG163
B	SER164

---

site_id	AE4
Number of Residues	3
Details	binding site for residue CL B 309

Chain	Residue
B	LYS218
B	GLY219
B	ILE92

---

site_id	AE5
Number of Residues	1
Details	binding site for residue CL B 310

Chain	Residue
B	SER168

---

site_id	AE6
Number of Residues	1
Details	binding site for residue CL B 311

Chain	Residue
B	TYR51

---

site_id	AE7
Number of Residues	5
Details	binding site for residue EDO B 312

Chain	Residue
B	LEU215
B	ASP216
B	HOH419
C	ASN242
C	GLY245

---

site_id	AE8
Number of Residues	4
Details	binding site for residue EDO B 313

Chain	Residue
B	PHE170
B	ARG172
B	GLU176
B	HOH435

---

site_id	AE9
Number of Residues	19
Details	binding site for residue 5XN C 301

Chain	Residue
C	GLU13
C	SER14
C	TYR16
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	GLY141
C	SER142
C	THR143
C	LEU192
C	GLU193
C	THR195
C	MET196
C	TYR220
C	TRP255
C	HOH409
C	HOH428

---

site_id	AF1
Number of Residues	4
Details	binding site for residue SO4 C 302

Chain	Residue
C	ARG64
C	ARG148
C	ARG149
C	HOH401

---

site_id	AF2
Number of Residues	3
Details	binding site for residue SO4 C 303

Chain	Residue
C	HIS46
C	LYS240
C	GLN244

---

site_id	AF3
Number of Residues	6
Details	binding site for residue GOL C 304

Chain	Residue
C	ASN22
C	MET25
C	ALA134
C	ARG180
C	SER184
C	TYR188

---

site_id	AF4
Number of Residues	6
Details	binding site for residue GOL C 305

Chain	Residue
C	GLY57
C	ASP58
C	GLY73
C	GLY76
C	GLU77
C	LYS82

---

site_id	AF5
Number of Residues	1
Details	binding site for residue CL C 306

Chain	Residue
C	SER108

---

site_id	AF6
Number of Residues	4
Details	binding site for residue EDO C 307

Chain	Residue
C	PHE170
C	ARG172
C	GLU176
C	HOH413

---

site_id	AF7
Number of Residues	2
Details	binding site for residue EDO C 308

Chain	Residue
C	THR173
C	GLU176

---

site_id	AF8
Number of Residues	5
Details	binding site for residue EDO C 309

Chain	Residue
B	LYS104
B	PRO105
C	ILE92
C	LYS218
C	GLY219

---

site_id	AF9
Number of Residues	2
Details	binding site for residue EDO C 310

Chain	Residue
C	ASN29
C	TYR51

---

site_id	AG1
Number of Residues	17
Details	binding site for residue 5XN D 301

Chain	Residue
D	GLU13
D	SER14
D	TYR16
D	TYR61
D	PRO89
D	LEU90
D	THR91
D	ARG96
D	GLY141
D	SER142
D	THR143
D	LEU192
D	GLU193
D	THR195
D	MET196
D	TYR220
D	HOH413

---

site_id	AG2
Number of Residues	2
Details	binding site for residue SO4 D 302

Chain	Residue
A	LYS240
D	ARG149

---

site_id	AG3
Number of Residues	1
Details	binding site for residue SO4 D 303

Chain	Residue
D	ARG148

---

site_id	AG4
Number of Residues	5
Details	binding site for residue GOL D 304

Chain	Residue
D	ASP65
D	THR68
D	ILE70
D	HOH416
D	HOH422

---

site_id	AG5
Number of Residues	1
Details	binding site for residue CL D 305

Chain	Residue
D	SER108

---

site_id	AG6
Number of Residues	1
Details	binding site for residue CL D 306

Chain	Residue
D	ALA153

---

site_id	AG7
Number of Residues	1
Details	binding site for residue CL D 307

Chain	Residue
D	LYS249

---

site_id	AG8
Number of Residues	5
Details	binding site for residue EDO D 308

Chain	Residue
D	PHE170
D	ARG172
D	GLU176
D	HOH417
D	HOH423

---

site_id	AG9
Number of Residues	5
Details	binding site for residue EDO D 309

Chain	Residue
A	LYS104
A	PRO105
D	ILE92
D	LYS218
D	GLY219

---

site_id	AH1
Number of Residues	3
Details	binding site for residue EDO D 310

Chain	Residue
D	LYS69
D	TYR80
D	HOH472

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
D	PRO89
A	THR91
D	THR91
D	ARG96
D	SER142
D	THR143
D	GLU193
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
D	ARG64
D	ARG148
D	LYS240
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121
D	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150
D	SER150

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184
D	SER184

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3
D	ASN3

---