5FHO

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-chlorobenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 2.3 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Glutamate receptor 2,Glutamate receptor 2	polymer	264	29278.7	4	UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Norway Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Ionotropic glutamate receptor A2,GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 Ionotropic glutamate receptor A2,
2	A, C, D, B	(1S)-1-carboxy-2-(5-{2-[(3-chlorophenyl)methyl]-2H-tetrazol-5-yl}-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)ethan-1-aminium	non-polymer		365.8	4	Chemie (5XN)
3	A, C, D, B	SULFATE ION	non-polymer		96.1	12	Chemie (SO4)
4	C, A, D, B	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
5	B, C, A, D	CHLORIDE ION	non-polymer		35.5	9	Chemie (CL)
6	B, C, A, D	1,2-ETHANEDIOL	non-polymer		62.1	14	Chemie (EDO)
7	B	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
8		water	water		18.0	413	Chemie (HOH)

Sequence modifications

A, B, C, D: 3 - 117 (UniProt: P19491)

PDB	External Database	Details
Gly 1	-	expression tag
Ala 2	-	expression tag

A, B, C, D: 120 - 264 (UniProt: P19491)

PDB	External Database	Details
Gly 118	-	linker
Thr 119	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	117114.9
Non-Polymers*	Number of molecules	46
	Total formula weight	4550.6
All*	Total formula weight	121665.5

*Water molecules are not included.