8JPX
 
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8JSI
 | | Cryo-EM structure of a DNA-protein complex | | 分子名称: | Argonaute family protein, DNA (5'-D(P*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*C)-3'), DNA (5'-D(P*GP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), ... | | 著者 | Li, Z. | | 登録日 | 2023-06-20 | | 公開日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Cryo-EM structure of a DNA-protein complex
To Be Published
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2F8T
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2F8S
 | | Crystal structure of Aa-Ago with externally-bound siRNA | | 分子名称: | 5'-R(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*AP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)-3', Argonaute protein | | 著者 | Yuan, Y.R, Chen, H.Y, Patel, D.J. | | 登録日 | 2005-12-03 | | 公開日 | 2006-10-31 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | A Potential Protein-RNA Recognition Event along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally Bound siRNA.
Structure, 14, 2006
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5G5T
 | | Structure of the Argonaute protein from Methanocaldcoccus janaschii in complex with guide DNA | | 分子名称: | ARGONAUTE, GUIDE DNA, MAGNESIUM ION, ... | | 著者 | Schneider, S, Oellig, C.A, Keegan, R, Grohmann, D, Zander, A, Willkomm, S. | | 登録日 | 2016-06-03 | | 公開日 | 2017-02-08 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.
Nat Microbiol, 2, 2017
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5G5S
 | | Structure of the Argonaute protein from Methanocaldcoccus janaschii | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ARGONAUTE, MAGNESIUM ION | | 著者 | Schneider, S, Oellig, C.A, Keegan, R, Grohmann, D, Zander, A, Willkomm, S. | | 登録日 | 2016-06-03 | | 公開日 | 2017-02-08 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.
Nat Microbiol, 2, 2017
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1Z26
 | | Structure of Pyrococcus furiosus Argonaute with bound tungstate | | 分子名称: | Argonaute, TUNGSTATE(VI)ION | | 著者 | Rivas, F.V, Tolia, N.H, Song, J.J, Aragon, J.P, Liu, J, Hannon, G.J, Joshua-Tor, L. | | 登録日 | 2005-03-07 | | 公開日 | 2005-04-05 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Purified Argonaute2 and an siRNA form recombinant human RISC.
Nat.Struct.Mol.Biol., 12, 2005
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1Z25
 | | Structure of P.furiosus Argonaute with bound Mn2+ | | 分子名称: | Argonaute, MANGANESE (II) ION | | 著者 | Rivas, F.V, Tolia, N.H, Song, J.J, Aragon, J.P, Liu, J, Hannon, G.J, Joshua-Tor, L. | | 登録日 | 2005-03-07 | | 公開日 | 2005-04-05 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Purified Argonaute2 and an siRNA form recombinant human RISC.
Nat.Struct.Mol.Biol., 12, 2005
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1YVU
 | | Crystal structure of A. aeolicus Argonaute | | 分子名称: | CALCIUM ION, hypothetical protein aq_1447 | | 著者 | Yuan, Y.R, Pei, Y, Ma, J.B, Kuryavyi, V, Zhadina, M, Meister, G, Chen, H.Y, Dauter, Z, Tuschl, T, Patel, D.J. | | 登録日 | 2005-02-16 | | 公開日 | 2005-08-09 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structure of A. aeolicus Argonaute provides unique perspectives into the mechanism of guide strand-mediated mRNA cleavage
Mol.Cell, 19, 2005
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6OON
 | | Human Argonaute4 bound to guide RNA | | 分子名称: | Protein argonaute-4, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*UP*U)-3') | | 著者 | Park, M.S, Brackbill, J.A, Nakanishi, K. | | 登録日 | 2019-04-23 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters.
Mol.Cell, 75, 2019
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4KXT
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4OLB
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4KRE
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4KRF
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5W6V
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4W5Q
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8D6J
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8D71
 | | Human Ago2 bound to miR122(21nt) | | 分子名称: | MAGNESIUM ION, Protein argonaute-2, miR-122-21nt | | 著者 | Xiao, Y, MacRae, I. | | 登録日 | 2022-06-07 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength.
Embo Rep., 24, 2023
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4W5R
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4OLA
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5WEA
 | | Human Argonaute2 Helix-7 Mutant | | 分子名称: | PHENOL, Protein argonaute-2, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*U)-3') | | 著者 | Schirle, N.T, Klum, S.M, MacRae, I.J. | | 登録日 | 2017-07-08 | | 公開日 | 2017-11-22 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | | 主引用文献 | Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition.
EMBO J., 37, 2018
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4F3T
 | | Human Argonaute-2 - miR-20a complex | | 分子名称: | PHENOL, Protein argonaute-2, RNA (5'-R(P*UP*AP*AP*AP*GP*UP*GP*CP*UP*UP*AP*UP*AP*GP*UP*G*CP*AP*GP*G)-3') | | 著者 | Elkayam, E, Kuhn, C.-D, Tocilj, A, Joshua-Tor, L. | | 登録日 | 2012-05-09 | | 公開日 | 2012-05-30 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | The Structure of Human Argonaute-2 in Complex with miR-20a.
Cell(Cambridge,Mass.), 150, 2012
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4F1N
 | | Crystal structure of Kluyveromyces polysporus Argonaute with a guide RNA | | 分子名称: | KpAGO, RNA 5'-R(P*UP*AP*AP*AP*AP*AP*AP*AP*A)-3' | | 著者 | Nakanishi, K, Weinberg, D.E, Bartel, D.P, Patel, D.J. | | 登録日 | 2012-05-07 | | 公開日 | 2012-06-13 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.187 Å) | | 主引用文献 | Structure of yeast Argonaute with guide RNA.
Nature, 486, 2012
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4W5T
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4W5N
 | | The Crystal Structure of Human Argonaute2 Bound to a Defined Guide RNA | | 分子名称: | MAGNESIUM ION, PHENOL, Protein argonaute-2, ... | | 著者 | Schirle, N.T, Sheu-Gruttadauria, J, MacRae, I.J. | | 登録日 | 2014-08-18 | | 公開日 | 2014-11-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014
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