5WEA
Human Argonaute2 Helix-7 Mutant
Summary for 5WEA
Entry DOI | 10.2210/pdb5wea/pdb |
Descriptor | Protein argonaute-2, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*U)-3'), PHENOL, ... (4 entities in total) |
Functional Keywords | argonaute, rna binding, rna silencing, microrna, hydrolase, hydrolase-rna complex, hydrolase/rna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 99959.76 |
Authors | Schirle, N.T.,Klum, S.M.,MacRae, I.J. (deposition date: 2017-07-08, release date: 2017-11-22, Last modification date: 2023-10-04) |
Primary citation | Klum, S.M.,Chandradoss, S.D.,Schirle, N.T.,Joo, C.,MacRae, I.J. Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition. EMBO J., 37:75-88, 2018 Cited by PubMed: 28939659DOI: 10.15252/embj.201796474 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.12 Å) |
Structure validation
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