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8EWI
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BU of 8ewi by Molmil
Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a tetrameric form
分子名称: E3 ubiquitin-protein ligase UBR5, ZINC ION
著者Wang, F, He, Q, Lin, G, Li, H.
登録日2022-10-23
公開日2023-04-19
最終更新日2023-05-17
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structure of the human UBR5 E3 ubiquitin ligase.
Structure, 31, 2023
7NH3
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BU of 7nh3 by Molmil
Nematocida Huwe1 in open conformation.
分子名称: E3 ubiquitin-protein ligase HUWE1
著者Petrova, O, Grishkovskaya, I, Grabarczyk, D.B, Kessler, D, Haselbach, D, Clausen, T.
登録日2021-02-09
公開日2022-03-02
最終更新日2023-07-26
実験手法ELECTRON MICROSCOPY (6.37 Å)
主引用文献Crystal structure of HUWE1: One ring to ubiquitinate them all
To Be Published
6XZ1
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BU of 6xz1 by Molmil
Conjugate of the HECT domain of HUWE1 with ubiquitin
分子名称: HECT, UBA and WWE domain containing 1, isoform CRA_a, ...
著者Liu, B, Seenivasan, A, Nair, R, Chen, D, Lowe, E.D, Lorenz, S.
登録日2020-01-31
公開日2021-08-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe.
Acs Chem.Biol., 16, 2021
7MWD
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BU of 7mwd by Molmil
HUWE1 in map with focus on HECT
分子名称: E3 ubiquitin-protein ligase HUWE1
著者Hunkeler, M, Fischer, E.S.
登録日2021-05-16
公開日2021-07-28
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
Mol.Cell, 81, 2021
7MWF
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BU of 7mwf by Molmil
HUWE1 in map with focus on interface
分子名称: E3 ubiquitin-protein ligase HUWE1
著者Hunkeler, M, Fischer, E.S.
登録日2021-05-16
公開日2021-07-28
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
Mol.Cell, 81, 2021
7MOP
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BU of 7mop by Molmil
Cryo-EM structure of human HUWE1 in complex with DDIT4
分子名称: DNA damage-inducible transcript 4 protein, E3 ubiquitin-protein ligase HUWE1
著者Hunkeler, M, Fischer, E.S.
登録日2021-05-03
公開日2021-07-28
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
Mol.Cell, 81, 2021
7MWE
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BU of 7mwe by Molmil
HUWE1 in map with focus on WWE
分子名称: E3 ubiquitin-protein ligase HUWE1
著者Hunkeler, M, Fischer, E.S.
登録日2021-05-16
公開日2021-07-28
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
Mol.Cell, 81, 2021
7JQ9
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BU of 7jq9 by Molmil
Cryo-EM structure of human HUWE1
分子名称: E3 ubiquitin-protein ligase HUWE1
著者Hunkeler, M, Fischer, E.S.
登録日2020-08-10
公開日2021-07-28
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
Mol.Cell, 81, 2021
7BII
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BU of 7bii by Molmil
Crystal structure of Nematocida HUWE1
分子名称: E3 ubiquitin-protein ligase HUWE1
著者Grabarczyk, D.B, Petrova, O.A, Meinhart, A, Kessler, D, Clausen, T.
登録日2021-01-12
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.037 Å)
主引用文献HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.
Nat.Chem.Biol., 17, 2021
7M3Q
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BU of 7m3q by Molmil
Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV)
分子名称: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHLORIDE ION, ...
著者Chowdhury, A, Singer, A.U, Ogunjimi, A.A, Teyra, J, Zhang, W, Sicheri, F, Sidhu, S.S.
登録日2021-03-18
公開日2021-04-21
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV)
To be published
6LOH
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BU of 6loh by Molmil
Crystal structure of the catalytic domain of human ubiquitin ligase AREL1
分子名称: Apoptosis-resistant E3 ubiquitin protein ligase 1
著者Chen, Z.Z, Li, Z.H, Shang, G.H.
登録日2020-01-05
公開日2021-01-20
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.207 Å)
主引用文献Crystal structure of the catalytic domain of human ubiquitin ligase AREL1
Prog.Biochem.Biophys., 2020
6K2C
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BU of 6k2c by Molmil
Extended Hect domain of UBE3C E3 Ligase
分子名称: Ubiquitin-protein ligase E3C
著者Sivaraman, J, Singh, S.
登録日2019-05-14
公開日2020-03-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.703 Å)
主引用文献Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity.
Biochem.J., 477, 2020
6TGK
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BU of 6tgk by Molmil
Domain swapped E6AP C-lobe dimer
分子名称: ACETATE ION, CALCIUM ION, Ubiquitin-protein ligase E3A
著者Ries, L.K, Feiler, C, Lowe, L.D, Liess, A.K.L, Lorenz, S.
登録日2019-11-16
公開日2020-02-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Crystal structure of the catalytic C-lobe of the HECT-type ubiquitin ligase E6AP.
Protein Sci., 29, 2020
6JX5
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BU of 6jx5 by Molmil
Hect domain of AREL1
分子名称: Apoptosis-resistant E3 ubiquitin protein ligase 1
著者Sivaraman, J, Singh, S, Ng, J, Nayak, D.
登録日2019-04-22
公開日2019-12-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.402 Å)
主引用文献Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activitiesin vitro.
J.Biol.Chem., 294, 2019
6J1Z
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BU of 6j1z by Molmil
WWP2 semi-open conformation
分子名称: NEDD4-like E3 ubiquitin-protein ligase WWP2
著者Liu, Z.H.
登録日2018-12-30
公開日2019-07-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.
Nat Commun, 10, 2019
6J1X
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BU of 6j1x by Molmil
WWP1 close conformation
分子名称: GLYCEROL, NEDD4-like E3 ubiquitin-protein ligase WWP1
著者Liu, Z.H.
登録日2018-12-30
公開日2019-07-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.
Nat Commun, 10, 2019
6J1Y
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BU of 6j1y by Molmil
Semi-open conformation E3 ligase
分子名称: GLYCEROL, NEDD4-like E3 ubiquitin-protein ligase WWP1
著者Liu, Z.H.
登録日2018-12-30
公開日2019-07-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.
Nat Commun, 10, 2019
6FYH
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BU of 6fyh by Molmil
Disulfide between ubiquitin G76C and the E3 HECT ligase Huwe1
分子名称: E3 ubiquitin-protein ligase HUWE1, Polyubiquitin-B, SULFATE ION, ...
著者Jaeckl, M, Hartmann, M.D, Wiesner, S.
登録日2018-03-12
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.906 Å)
主引用文献beta-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.
J. Mol. Biol., 430, 2018
6FX4
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BU of 6fx4 by Molmil
Disulfide between E3 HECT ligase Smurf2 and Ubiquitin G76C
分子名称: E3 ubiquitin-protein ligase SMURF2, GLYCEROL, Polyubiquitin-B
著者Jaeckl, M, Holdermann, I, Wiesner, S.
登録日2018-03-08
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献beta-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.
J. Mol. Biol., 430, 2018
5W87
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BU of 5w87 by Molmil
Crystal structure of the C-terminal lobe of the human HERC6 HECT domain
分子名称: PHOSPHATE ION, Probable E3 ubiquitin-protein ligase HERC6
著者WANG, Y, BELLESIS, A.G, ROYER, W.E, SPRATT, D.E.
登録日2017-06-21
公開日2018-07-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.199 Å)
主引用文献Crystal structure of the C-terminal lobe of the human HERC6 HECT domain
To Be Published
5XMC
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BU of 5xmc by Molmil
Crystal structure of the auto-inhibited Nedd4 family E3 ligase Itch
分子名称: E3 ubiquitin-protein ligase Itchy
著者Shan, Z, Wen, W.
登録日2017-05-13
公開日2017-08-02
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch
EMBO Rep., 18, 2017
5TJ8
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BU of 5tj8 by Molmil
Structure of WWP2 WW2-2,3-linker-HECT (no WW2 observed)
分子名称: NEDD4-like E3 ubiquitin-protein ligase WWP2,NEDD4-like E3 ubiquitin-protein ligase WWP2, SODIUM ION
著者Chen, Z, Gabelli, S.B.
登録日2016-10-03
公開日2017-06-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A Tunable Brake for HECT Ubiquitin Ligases.
Mol. Cell, 66, 2017
5TJ7
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BU of 5tj7 by Molmil
Structure of WWP2 WW2-2,3-linker-HECT aa 334-398 linked to 485-865
分子名称: CHLORIDE ION, NEDD4-like E3 ubiquitin-protein ligase WWP2, SODIUM ION, ...
著者Chen, Z, Gabelli, S.B.
登録日2016-10-03
公開日2017-05-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A Tunable Brake for HECT Ubiquitin Ligases.
Mol. Cell, 66, 2017
5TJQ
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BU of 5tjq by Molmil
Structure of WWP2 2,3-linker-HECT
分子名称: NEDD4-like E3 ubiquitin-protein ligase WWP2,NEDD4-like E3 ubiquitin-protein ligase WWP2
著者Chen, Z, Gabelli, S.B.
登録日2016-10-04
公開日2017-05-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献A Tunable Brake for HECT Ubiquitin Ligases.
Mol. Cell, 66, 2017
5LP8
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BU of 5lp8 by Molmil
Crystal structure of an asymmetric dimer of the ubiquitin ligase HUWE1
分子名称: E3 ubiquitin-protein ligase HUWE1
著者Sander, B, Lorenz, S.G.
登録日2016-08-12
公開日2017-02-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A conformational switch regulates the ubiquitin ligase HUWE1.
Elife, 6, 2017

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