7MOP

Cryo-EM structure of human HUWE1 in complex with DDIT4

Summary for 7MOP

• Entry DOI: 10.2210/pdb7mop/pdb
• Related: 7JQ9
• EMDB information: 22427 22428 22429 22430 22431 23925
• Descriptor: E3 ubiquitin-protein ligase HUWE1, DNA damage-inducible transcript 4 protein (2 entities in total)
• Functional Keywords: ubiquitin, quality control, e3 ligase, protein degradation, transferase, transferase-apoptosis complex, transferase/apoptosis
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 514846.35

Authors

Hunkeler, M.,Fischer, E.S. (deposition date: 2021-05-03, release date: 2021-07-28, Last modification date: 2021-09-15)

• Primary citation: Hunkeler, M.,Jin, C.Y.,Ma, M.W.,Monda, J.K.,Overwijn, D.,Bennett, E.J.,Fischer, E.S.; Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.; Mol.Cell, 81:3468-, 2021; PubMed: 34314700; DOI: 10.1016/j.molcel.2021.06.032

Experimental method

ELECTRON MICROSCOPY (3.3 Å)