PDB: 128 件ウェブページステータス検索Chemie searchBIRD

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6J74	Complex of GGTaseIII and full-length Ykt6 分子名称: Geranylgeranyl transferase type-2 subunit beta, PHOSPHATE ION, Protein prenyltransferase alpha subunit repeat-containing protein 1, ... 著者 Goto-Ito, S, Yamagata, A, Sato, Y, Fukai, S. 登録日 2019-01-16 公開日 2020-01-22 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.212 Å) 主引用文献 Complex of GGTaseIII and full-length Ykt6 To Be Published
6J7F	Complex of GGTaseIII, farnesyl-Ykt6 (C-terminal methylated), and GGPP 分子名称: DIPHOSPHATE, FARNESYL, GERAN-8-YL GERAN, ... 著者 Goto-Ito, S, Yamagata, A, Sato, Y, Fukai, S. 登録日 2019-01-18 公開日 2020-01-22 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.883 Å) 主引用文献 Complex of GGTaseIII, farnesyl-Ykt6 (C-terminal methylated), and GGPP To Be Published
4LNG	Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib 分子名称: 1,2-ETHANEDIOL, 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE, CaaX farnesyltransferase alpha subunit Ram2, ... 著者 Mabanglo, M.F, Hast, M.A, Beese, L.S. 登録日 2013-07-11 公開日 2014-01-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.905 Å) 主引用文献 Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23, 2014
4L9P	Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, CaaX farnesyltransferase alpha subunit Ram2, ... 著者 Mabanglo, M.F, Hast, M.A, Beese, L.S. 登録日 2013-06-18 公開日 2014-01-01 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23, 2014
4LNB	Aspergillus fumigatus protein farnesyltransferase ternary complex with farnesyldiphosphate and ethylenediamine scaffold inhibitor 5 分子名称: 1,2-ETHANEDIOL, CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, ... 著者 Mabanglo, M.F, Hast, M.A, Beese, L.S. 登録日 2013-07-11 公開日 2014-01-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.752 Å) 主引用文献 Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23, 2014
4MBG	Crystal structure of Aspergillus fumigatus protein farnesyltransferase binary complex with farnesyldiphosphate 分子名称: 1,2-ETHANEDIOL, CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, ... 著者 Mabanglo, M.F, Hast, M.A, Beese, L.S. 登録日 2013-08-19 公開日 2014-01-01 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23, 2014
6J7X	Complex of GGTaseIII, farnesyl-Ykt6, and GGPP 分子名称: FORMIC ACID, GERANYLGERANYL DIPHOSPHATE, Geranylgeranyl transferase type-2 subunit beta, ... 著者 Goto-Ito, S, Yamagata, A, Sato, Y, Fukai, S. 登録日 2019-01-18 公開日 2020-01-22 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Complex of GGTaseIII, farnesyl-Ykt6 (C-terminal methylated), and GGPP To Be Published
3PZ4	Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP 分子名称: (3R)-3-benzyl-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile, FARNESYL DIPHOSPHATE, Protein farnesyltransferase subunit beta, ... 著者 Guo, Z, Bon, R.S, Stigter, E.A, Waldmann, H, Alexandrov, K, Blankenfeldt, W, Goody, R.S. 登録日 2010-12-14 公開日 2011-05-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-Guided Development of Selective RabGGTase Inhibitors. Angew.Chem.Int.Ed.Engl., 50, 2011
3PZ3	Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS-analogue 14 分子名称: 4-({(3R)-7-(5-formylfuran-2-yl)-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl}methyl)phenyl benzylcarbamate, CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, ... 著者 Guo, Z, Bon, R.S, Stigter, E.A, Waldmann, H, Alexandrov, K, Blankenfeldt, W, Goody, R.S. 登録日 2010-12-14 公開日 2011-05-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-Guided Development of Selective RabGGTase Inhibitors. Angew.Chem.Int.Ed.Engl., 50, 2011
3PZ1	Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 分子名称: (3R)-3-benzyl-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile, CALCIUM ION, DIMETHYL SULFOXIDE, ... 著者 Guo, Z, Bon, R.S, Stigter, E.A, Waldmann, H, Alexandrov, K, Blankenfeldt, W, Goody, R.S. 登録日 2010-12-14 公開日 2011-05-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure-Guided Development of Selective RabGGTase Inhibitors. Angew.Chem.Int.Ed.Engl., 50, 2011
3PZ2	Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP 分子名称: (3R)-3-benzyl-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile, CALCIUM ION, GERANYLGERANYL DIPHOSPHATE, ... 著者 Guo, Z, Bon, R.S, Stigter, E.A, Waldmann, H, Alexandrov, K, Blankenfeldt, W, Goody, R.S. 登録日 2010-12-14 公開日 2011-05-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure-Guided Development of Selective RabGGTase Inhibitors. Angew.Chem.Int.Ed.Engl., 50, 2011
1MZC	Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a 分子名称: 2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]-4-[1-AMINO-1-(1-METHYL-1H-IMIDIZOL-5-YL)-ETHYL]-BENZONITRILE, FARNESYL DIPHOSPHATE, Protein Farnesyltransferase alpha Subunit, ... 著者 deSolms, S.J, Ciccarone, T.M, MacTough, S.C, Shaw, A.W, Buser, C.A, Ellis-Hutchings, M, Fernandes, C, Hamilton, K.A, Huber, H.E, Kohl, N.E, Lobell, R.B, Robinson, R.G, Tsou, N.N, Walsh, E.S, Graham, S.L, Beese, L.S, Taylor, J.S. 登録日 2002-10-07 公開日 2003-07-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Dual Protein Farnesyltransferase-Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents. J.Med.Chem., 46, 2003
1N4R	Protein Geranylgeranyltransferase type-I Complexed with a Geranylgeranylated KKKSKTKCVIL Peptide Product 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, Fusion protein consisting of transforming protein p21b and Ras related protein Rap-2b, ... 著者 Taylor, J.S, Reid, T.S, Casey, P.J, Beese, L.S. 登録日 2002-11-01 公開日 2003-11-18 最終更新日 2017-06-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of mammalian protein geranylgeranyltransferase type-I EMBO J., 22, 2003
1N4P	Protein Geranylgeranyltransferase type-I Complexed with Geranylgeranyl Diphosphate 分子名称: CHLORIDE ION, Fusion protein consisting of transforming protein p21b and Ras related protein Rap-2b, GERAN-8-YL GERAN, ... 著者 Taylor, J.S, Reid, T.S, Casey, P.J, Beese, L.S. 登録日 2002-11-01 公開日 2003-11-18 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure of mammalian protein geranylgeranyltransferase type-I EMBO J., 22, 2003
1N4Q	Protein Geranylgeranyltransferase type-I Complexed with a GGPP Analog and a KKKSKTKCVIL Peptide 分子名称: 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE, CHLORIDE ION, Fusion protein consisting of transforming protein p21b and Ras related protein Rap-2b, ... 著者 Taylor, J.S, Reid, T.S, Casey, P.J, Beese, L.S. 登録日 2002-11-01 公開日 2003-11-18 最終更新日 2017-06-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of mammalian protein geranylgeranyltransferase type-I EMBO J., 22, 2003
1N4S	Protein Geranylgeranyltransferase type-I Complexed with GGPP and a Geranylgeranylated KKKSKTKCVIL Peptide Product 分子名称: CHLORIDE ION, Fusion protein consisting of transforming protein p21b and Ras related protein Rap-2b, GERAN-8-YL GERAN, ... 著者 Taylor, J.S, Reid, T.S, Casey, P.J, Beese, L.S. 登録日 2002-11-01 公開日 2003-11-18 最終更新日 2017-06-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of mammalian protein geranylgeranyltransferase type-I EMBO J., 22, 2003
3HXD	Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 9) 分子名称: CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... 著者 Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. 登録日 2009-06-20 公開日 2009-09-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors J.Med.Chem., 52, 2009
3HXF	Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 32) 分子名称: CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... 著者 Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. 登録日 2009-06-20 公開日 2009-09-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors J.Med.Chem., 52, 2009
3HXC	Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 8) 分子名称: CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... 著者 Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. 登録日 2009-06-20 公開日 2009-09-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors J.Med.Chem., 52, 2009
2IEJ	Human Protein Farnesyltransferase Complexed with Inhibitor Compound STN-48 And FPP Analog at 1.8A Resolution 分子名称: ACETATE ION, METHYL N-{(3S)-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-6-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-3-YL}-N-[(1-METHYL-1H-IMIDAZOL-4-YL)SULFONYL]GLYCINATE, Protein farnesyltransferase subunit beta, ... 著者 Hast, M.A, Beese, L.S. 登録日 2006-09-19 公開日 2007-01-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Mol.Biochem.Parasitol., 152, 2007
3HXB	Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 6) 分子名称: Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, N-[(benzyloxy)carbonyl]-D-tyrosyl-L-phenylalanyl-L-tyrosine, ... 著者 Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. 登録日 2009-06-20 公開日 2009-09-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors J.Med.Chem., 52, 2009
2H6I	W102T/Y365F Protein Farnesyltransferase Double Mutant Complexed with a Geranylgeranylated DDPTASACVLS Peptide Product at 3.0A 分子名称: GERAN-8-YL GERAN, Protein farnesyltransferase beta subunit, Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, ... 著者 Terry, K.L, Beese, L.S. 登録日 2006-05-31 公開日 2006-08-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry, 45, 2006
3SQC	SQUALENE-HOPENE CYCLASE 分子名称: SQUALENE--HOPENE CYCLASE 著者 Wendt, K.U, Schulz, G.E. 登録日 1998-09-04 公開日 1999-05-18 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution. J.Mol.Biol., 286, 1999
2H6H	Y365F Protein Farnesyltransferase Mutant Complexed with a Farnesylated DDPTASACVLS Peptide Product at 1.8A 分子名称: ACETIC ACID, FARNESYL, Protein farnesyltransferase beta subunit, ... 著者 Terry, K.L, Beese, L.S. 登録日 2006-05-31 公開日 2006-08-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry, 45, 2006
3HXE	Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 37) 分子名称: CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ... 著者 Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. 登録日 2009-06-20 公開日 2009-09-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors J.Med.Chem., 52, 2009

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