4MBG
Crystal structure of Aspergillus fumigatus protein farnesyltransferase binary complex with farnesyldiphosphate
Summary for 4MBG
| Entry DOI | 10.2210/pdb4mbg/pdb |
| Related | 4L9P 4LNB 4LNG |
| Descriptor | CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, 1,2-ETHANEDIOL, ... (7 entities in total) |
| Functional Keywords | farnesyldiphosphate, farnesyltransferase inhibitor, transferase |
| Biological source | Aspergillus fumigatus More |
| Total number of polymer chains | 2 |
| Total formula weight | 99886.51 |
| Authors | Mabanglo, M.F.,Hast, M.A.,Beese, L.S. (deposition date: 2013-08-19, release date: 2014-01-01, Last modification date: 2024-04-03) |
| Primary citation | Mabanglo, M.F.,Hast, M.A.,Lubock, N.B.,Hellinga, H.W.,Beese, L.S. Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23:289-301, 2014 Cited by PubMed: 24347326DOI: 10.1002/pro.2411 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.74 Å) |
Structure validation
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