4MBG
Crystal structure of Aspergillus fumigatus protein farnesyltransferase binary complex with farnesyldiphosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0004660 | molecular_function | protein farnesyltransferase activity |
| A | 0004662 | molecular_function | CAAX-protein geranylgeranyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005953 | cellular_component | CAAX-protein geranylgeranyltransferase complex |
| A | 0005965 | cellular_component | protein farnesyltransferase complex |
| A | 0007323 | biological_process | peptide pheromone maturation |
| A | 0008318 | molecular_function | protein prenyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018342 | biological_process | protein prenylation |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0004660 | molecular_function | protein farnesyltransferase activity |
| B | 0005965 | cellular_component | protein farnesyltransferase complex |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008318 | molecular_function | protein prenyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0018343 | biological_process | protein farnesylation |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0097354 | biological_process | prenylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 401 |
| Chain | Residue |
| A | TYR35 |
| A | THR43 |
| A | ARG47 |
| A | EDO402 |
| A | HOH561 |
| A | HOH648 |
| B | ASP148 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 402 |
| Chain | Residue |
| A | ARG47 |
| A | MET50 |
| A | HIS73 |
| A | EDO401 |
| B | HIS194 |
| B | GLY195 |
| A | THR43 |
| A | LEU46 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 403 |
| Chain | Residue |
| A | GLN116 |
| A | HOH519 |
| A | HOH553 |
| A | HOH644 |
| B | GLU249 |
| B | SER305 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE FPP B 601 |
| Chain | Residue |
| A | TYR147 |
| B | TRP153 |
| B | ARG252 |
| B | TYR255 |
| B | HIS311 |
| B | ALA313 |
| B | TYR314 |
| B | CYS317 |
| B | ARG359 |
| B | LYS362 |
| B | TYR368 |
| B | TRP371 |
| B | TYR432 |
| B | HOH702 |
| B | HOH704 |
| B | HOH711 |
| B | HOH722 |
| B | HOH783 |
| B | HOH1066 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 602 |
| Chain | Residue |
| B | ASP365 |
| B | CYS367 |
| B | HIS433 |
| B | HOH1079 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 603 |
| Chain | Residue |
| B | ASP135 |
| B | ASP139 |
| B | TYR140 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 604 |
| Chain | Residue |
| B | TYR140 |
| B | MET154 |
| B | TRP157 |
| B | ASP430 |
| B | SER431 |
| B | HOH814 |
| B | HOH850 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K B 605 |
| Chain | Residue |
| B | TRP153 |
| B | ALA201 |
| B | ARG252 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 606 |
| Chain | Residue |
| B | HOH728 |
| B | HOH730 |
| B | HOH742 |
| B | HOH857 |
