4L9P

Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide

Summary for 4L9P

• Entry DOI: 10.2210/pdb4l9p/pdb
• Related: 4LNB 4LNG
• Descriptor: CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, LYS-CYS-VAL-VAL-MET (CAAX peptide), ... (8 entities in total)
• Functional Keywords: ternary complex with isoprenoid and caax peptide substrate, caax farnesyltransferase, isoprenoid and caax protein/peptide substrate, transferase
• Biological source: Aspergillus fumigatus; More
• Total number of polymer chains: 3
• Total formula weight: 100696.84

Authors

Mabanglo, M.F.,Hast, M.A.,Beese, L.S. (deposition date: 2013-06-18, release date: 2014-01-01, Last modification date: 2024-04-03)

• Primary citation: Mabanglo, M.F.,Hast, M.A.,Lubock, N.B.,Hellinga, H.W.,Beese, L.S.; Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.; Protein Sci., 23:289-301, 2014; PubMed: 24347326; DOI: 10.1002/pro.2411

Experimental method

X-RAY DIFFRACTION (1.45 Å)