4L9P
Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide
Summary for 4L9P
Entry DOI | 10.2210/pdb4l9p/pdb |
Related | 4LNB 4LNG |
Descriptor | CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, LYS-CYS-VAL-VAL-MET (CAAX peptide), ... (8 entities in total) |
Functional Keywords | ternary complex with isoprenoid and caax peptide substrate, caax farnesyltransferase, isoprenoid and caax protein/peptide substrate, transferase |
Biological source | Aspergillus fumigatus More |
Total number of polymer chains | 3 |
Total formula weight | 100696.84 |
Authors | Mabanglo, M.F.,Hast, M.A.,Beese, L.S. (deposition date: 2013-06-18, release date: 2014-01-01, Last modification date: 2024-04-03) |
Primary citation | Mabanglo, M.F.,Hast, M.A.,Lubock, N.B.,Hellinga, H.W.,Beese, L.S. Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. Protein Sci., 23:289-301, 2014 Cited by PubMed: 24347326DOI: 10.1002/pro.2411 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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