4L9P
Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0004660 | molecular_function | protein farnesyltransferase activity |
| A | 0004662 | molecular_function | CAAX-protein geranylgeranyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005953 | cellular_component | CAAX-protein geranylgeranyltransferase complex |
| A | 0005965 | cellular_component | protein farnesyltransferase complex |
| A | 0007323 | biological_process | peptide pheromone maturation |
| A | 0008318 | molecular_function | protein prenyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018342 | biological_process | protein prenylation |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0004660 | molecular_function | protein farnesyltransferase activity |
| B | 0005965 | cellular_component | protein farnesyltransferase complex |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008318 | molecular_function | protein prenyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0018343 | biological_process | protein farnesylation |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0097354 | biological_process | prenylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 402 |
| Chain | Residue |
| A | PRO129 |
| A | PRO130 |
| A | ARG131 |
| A | GLU132 |
| A | HOH520 |
| B | HOH891 |
| B | HOH920 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 403 |
| Chain | Residue |
| A | ARG47 |
| A | MET50 |
| A | HIS73 |
| A | EDO404 |
| B | HIS194 |
| B | GLY195 |
| A | THR43 |
| A | LEU46 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 404 |
| Chain | Residue |
| A | TYR35 |
| A | THR43 |
| A | ARG47 |
| A | EDO403 |
| A | HOH535 |
| A | HOH599 |
| B | ASP148 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 405 |
| Chain | Residue |
| A | GLU243 |
| A | TYR324 |
| A | ASP325 |
| A | HOH528 |
| A | HOH548 |
| B | HOH926 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 406 |
| Chain | Residue |
| A | GLN116 |
| A | HOH623 |
| B | EDO607 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 601 |
| Chain | Residue |
| B | ASP365 |
| B | CYS367 |
| B | HIS433 |
| C | CYS8 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 602 |
| Chain | Residue |
| B | LYS417 |
| B | ARG422 |
| B | HOH1009 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 603 |
| Chain | Residue |
| B | HOH910 |
| B | HOH1046 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 604 |
| Chain | Residue |
| B | TYR132 |
| B | MET154 |
| B | ASP430 |
| B | SER431 |
| B | HOH776 |
| B | HOH1048 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 605 |
| Chain | Residue |
| B | GLN94 |
| B | TYR350 |
| B | HOH731 |
| B | HOH736 |
| B | HOH952 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 606 |
| Chain | Residue |
| B | GLN236 |
| B | PRO237 |
| B | ASP238 |
| B | GLU249 |
| B | EDO607 |
| B | HOH1042 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 607 |
| Chain | Residue |
| A | HIS113 |
| A | GLN116 |
| A | EDO406 |
| B | GLY247 |
| B | GLU249 |
| B | EDO606 |
| site_id | BC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE FII B 608 |
| Chain | Residue |
| A | LYS107 |
| A | TYR109 |
| A | TYR147 |
| B | HIS311 |
| B | ALA313 |
| B | TYR314 |
| B | CYS317 |
| B | ARG359 |
| B | LYS362 |
| B | TYR368 |
| B | TRP371 |
| B | TYR432 |
| B | HOH705 |
| B | HOH708 |
| B | HOH709 |
| B | HOH710 |
| B | HOH788 |
| B | HOH954 |
| site_id | BC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR CHAIN C OF LYS-CYS-VAL-VAL-MET (CAAX PEPTIDE) |
| Chain | Residue |
| C | HOH105 |
| C | HOH106 |
| C | HOH107 |
| C | HOH108 |
| C | HOH109 |
| A | LYS107 |
| A | TYR109 |
| A | GLN110 |
| A | HOH578 |
| A | HOH799 |
| A | HOH845 |
| B | TRP153 |
| B | ARG252 |
| B | ASP365 |
| B | TYR432 |
| B | HIS433 |
| B | ZN601 |
| B | HOH766 |
| B | HOH788 |
| B | HOH1115 |
| C | HOH101 |
| C | HOH102 |
| C | HOH103 |
