4L9P
Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004659 | molecular_function | prenyltransferase activity |
A | 0004660 | molecular_function | protein farnesyltransferase activity |
A | 0004661 | molecular_function | protein geranylgeranyltransferase activity |
A | 0004662 | molecular_function | CAAX-protein geranylgeranyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005953 | cellular_component | CAAX-protein geranylgeranyltransferase complex |
A | 0005965 | cellular_component | protein farnesyltransferase complex |
A | 0007323 | biological_process | peptide pheromone maturation |
A | 0008318 | molecular_function | protein prenyltransferase activity |
A | 0018342 | biological_process | protein prenylation |
A | 0018343 | biological_process | protein farnesylation |
B | 0003824 | molecular_function | catalytic activity |
B | 0004659 | molecular_function | prenyltransferase activity |
B | 0004660 | molecular_function | protein farnesyltransferase activity |
B | 0005965 | cellular_component | protein farnesyltransferase complex |
B | 0008270 | molecular_function | zinc ion binding |
B | 0008318 | molecular_function | protein prenyltransferase activity |
B | 0016853 | molecular_function | isomerase activity |
B | 0018343 | biological_process | protein farnesylation |
B | 0046872 | molecular_function | metal ion binding |
B | 0097354 | biological_process | prenylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 402 |
Chain | Residue |
A | PRO129 |
A | PRO130 |
A | ARG131 |
A | GLU132 |
A | HOH520 |
B | HOH891 |
B | HOH920 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO A 403 |
Chain | Residue |
A | ARG47 |
A | MET50 |
A | HIS73 |
A | EDO404 |
B | HIS194 |
B | GLY195 |
A | THR43 |
A | LEU46 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 404 |
Chain | Residue |
A | TYR35 |
A | THR43 |
A | ARG47 |
A | EDO403 |
A | HOH535 |
A | HOH599 |
B | ASP148 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 405 |
Chain | Residue |
A | GLU243 |
A | TYR324 |
A | ASP325 |
A | HOH528 |
A | HOH548 |
B | HOH926 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 406 |
Chain | Residue |
A | GLN116 |
A | HOH623 |
B | EDO607 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 601 |
Chain | Residue |
B | ASP365 |
B | CYS367 |
B | HIS433 |
C | CYS8 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL B 602 |
Chain | Residue |
B | LYS417 |
B | ARG422 |
B | HOH1009 |
site_id | AC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL B 603 |
Chain | Residue |
B | HOH910 |
B | HOH1046 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B 604 |
Chain | Residue |
B | TYR132 |
B | MET154 |
B | ASP430 |
B | SER431 |
B | HOH776 |
B | HOH1048 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 605 |
Chain | Residue |
B | GLN94 |
B | TYR350 |
B | HOH731 |
B | HOH736 |
B | HOH952 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B 606 |
Chain | Residue |
B | GLN236 |
B | PRO237 |
B | ASP238 |
B | GLU249 |
B | EDO607 |
B | HOH1042 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B 607 |
Chain | Residue |
A | HIS113 |
A | GLN116 |
A | EDO406 |
B | GLY247 |
B | GLU249 |
B | EDO606 |
site_id | BC4 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE FII B 608 |
Chain | Residue |
A | LYS107 |
A | TYR109 |
A | TYR147 |
B | HIS311 |
B | ALA313 |
B | TYR314 |
B | CYS317 |
B | ARG359 |
B | LYS362 |
B | TYR368 |
B | TRP371 |
B | TYR432 |
B | HOH705 |
B | HOH708 |
B | HOH709 |
B | HOH710 |
B | HOH788 |
B | HOH954 |
site_id | BC5 |
Number of Residues | 23 |
Details | BINDING SITE FOR CHAIN C OF LYS-CYS-VAL-VAL-MET (CAAX PEPTIDE) |
Chain | Residue |
C | HOH105 |
C | HOH106 |
C | HOH107 |
C | HOH108 |
C | HOH109 |
A | LYS107 |
A | TYR109 |
A | GLN110 |
A | HOH578 |
A | HOH799 |
A | HOH845 |
B | TRP153 |
B | ARG252 |
B | ASP365 |
B | TYR432 |
B | HIS433 |
B | ZN601 |
B | HOH766 |
B | HOH788 |
B | HOH1115 |
C | HOH101 |
C | HOH102 |
C | HOH103 |