4L9P
Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CaaX farnesyltransferase alpha subunit Ram2 | polymer | 367 | 42391.5 | 1 | UniProt (Q4WP27) Pfam (PF01239) | Aspergillus fumigatus | |
| 2 | B (B) | CaaX farnesyltransferase beta subunit Ram1 | polymer | 519 | 56635.8 | 1 | UniProt (Q4WPS9) Pfam (PF00432) | Aspergillus fumigatus | |
| 3 | C (C) | LYS-CYS-VAL-VAL-MET (CAAX peptide) | polymer | 5 | 579.8 | 1 | |||
| 4 | D, K, L (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | E, F, G, H, I... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 6 | J (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 7 | Q (B) | [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID | non-polymer | 359.4 | 1 | Chemie (FII) | |||
| 8 | R, S, T (A, B, C) | water | water | 18.0 | 778 | Chemie (HOH) |
Sequence modifications
A: 1 - 353 (UniProt: Q4WP27)
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | initiating methionine |
| Gly -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Ser -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Ser 146 | Asn 146 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 99607.1 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1089.8 | |
| All* | Total formula weight | 100696.8 |
