6WRX
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![BU of 6wrx by Molmil](/molmil-images/mine/6wrx) | Crystal structure of computationally designed protein 2DS25.1 in complex with the human Transferrin receptor ectodomain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Abraham, J, Coscia, A, Olal, D, Sahtoe, D.D, Baker, D, Clark, L. | 登録日 | 2020-04-30 | 公開日 | 2021-04-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | 主引用文献 | Transferrin receptor targeting by de novo sheet extension. Proc.Natl.Acad.Sci.USA, 118, 2021
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6WRV
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![BU of 6wrv by Molmil](/molmil-images/mine/6wrv) | Crystal structure of computationally designed protein 3DS18 in complex with the human Transferrin receptor ectodomain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Computationally designed protein 3DS18, ... | 著者 | Abraham, J, Baker, D, Sahtoe, D.D, Coscia, A, Clark, L, Olal, D. | 登録日 | 2020-04-30 | 公開日 | 2021-04-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Transferrin receptor targeting by de novo sheet extension. Proc.Natl.Acad.Sci.USA, 118, 2021
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4JXI
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![BU of 4jxi by Molmil](/molmil-images/mine/4jxi) | Directed evolution and rational design of a de novo designed esterase toward improved catalysis. Northeast Structural Genomics Consortium (NESG) Target OR184 | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, BROMIDE ION, GLYCEROL, ... | 著者 | Kuzin, A, Smith, M.D, Richter, F, Lew, S, Seetharaman, R, Bryan, C, Lech, Z, Kiss, G, Moretti, R, Maglaqui, M, Xiao, R, Kohan, E, Smith, M, Everett, J.K, Nguyen, R, Pande, V, Hilvert, D, Kornhaber, G, Baker, D, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2013-03-28 | 公開日 | 2013-05-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Directed evolution and rational design of a de novo designed esterase toward improved catalysis. Northeast Structural Genomics Consortium (NESG) Target OR184 To be Published
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5KB2
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![BU of 5kb2 by Molmil](/molmil-images/mine/5kb2) | Crystal Structure of a Tris-thiolate Zn(II)S3O Complex in a de Novo Three-stranded Coiled Coil Peptide | 分子名称: | ZINC ION, Zn(II)(H2O)(GRAND Coil Ser-L12AL16C)3- | 著者 | Ruckthong, L, Zastrow, M.L, Stuckey, J.A, Pecoraro, V.L. | 登録日 | 2016-06-02 | 公開日 | 2016-08-31 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | A Crystallographic Examination of Predisposition versus Preorganization in de Novo Designed Metalloproteins. J.Am.Chem.Soc., 138, 2016
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2QRV
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![BU of 2qrv by Molmil](/molmil-images/mine/2qrv) | Structure of Dnmt3a-Dnmt3L C-terminal domain complex | 分子名称: | DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Jia, D, Cheng, X. | 登録日 | 2007-07-29 | 公開日 | 2007-12-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature, 449, 2007
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4C11
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![BU of 4c11 by Molmil](/molmil-images/mine/4c11) | |
5KB1
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![BU of 5kb1 by Molmil](/molmil-images/mine/5kb1) | Crystal Structure of a Tris-thiolate Hg(II) Complex in a de Novo Three Stranded Coiled Coil Peptide | 分子名称: | CHLORIDE ION, Hg(II)Zn(II)(GRAND Coil Ser-L16CL30H)3+, MERCURY (II) ION, ... | 著者 | Ruckcthong, L, Zastrow, M.L, Stuckey, J.A, Pecoraro, V.L. | 登録日 | 2016-06-02 | 公開日 | 2016-08-31 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | A Crystallographic Examination of Predisposition versus Preorganization in de Novo Designed Metalloproteins. J.Am.Chem.Soc., 138, 2016
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6WRW
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![BU of 6wrw by Molmil](/molmil-images/mine/6wrw) | Crystal structure of computationally designed protein 2DS25.5 in complex with the human Transferrin receptor ectodomain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Computationally designed protein 2DS25.5, ... | 著者 | Abraham, J, Coscia, A, Olal, D, Sahtoe, D.D, Baker, D, Clark, L. | 登録日 | 2020-04-30 | 公開日 | 2021-04-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Transferrin receptor targeting by de novo sheet extension. Proc.Natl.Acad.Sci.USA, 118, 2021
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7BWW
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![BU of 7bww by Molmil](/molmil-images/mine/7bww) | Structure of the engineered metallo-Diels-Alderase DA7 W16S | 分子名称: | ACETIC ACID, BENZOIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Basler, S, Mori, T, Hilvert, D. | 登録日 | 2020-04-16 | 公開日 | 2021-04-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold. Nat.Chem., 13, 2021
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7BAT
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![BU of 7bat by Molmil](/molmil-images/mine/7bat) | A hexameric barrel state of a de novo coiled-coil assembly: CC-Type2-(GgIaId)4 | 分子名称: | CC-Type2-(GgIaId)4, N-PROPANOL | 著者 | Martin, F.J.O, Dawson, W.M, Shelley, K, Brady, R.L, Woolfson, D.N. | 登録日 | 2020-12-16 | 公開日 | 2021-04-28 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states. Chem Sci, 12, 2021
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7BAS
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![BU of 7bas by Molmil](/molmil-images/mine/7bas) | A de novo pentameric coiled-coil assembly: CC-Type2-(TgLaId)4-W19BrPhe. | 分子名称: | CC-Type2-(TgLaId)4-W19BrPhe. | 著者 | Martin, F.J.O, Dawson, W.M, Shelley, K, Brady, R.L, Woolfson, D.N. | 登録日 | 2020-12-16 | 公開日 | 2021-04-28 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states. Chem Sci, 12, 2021
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7BAU
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![BU of 7bau by Molmil](/molmil-images/mine/7bau) | A de novo pentameric coiled-coil assembly: CC-Type2-(TgIaId)4-W19BrPhe. | 分子名称: | CC-Type2-(TgLaId)4-W19BrPhe. | 著者 | Martin, F.J.O, Dawson, W.M, Shelley, K, Brady, R.L, Woolfson, D.N. | 登録日 | 2020-12-16 | 公開日 | 2021-04-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states. Chem Sci, 12, 2021
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7BAV
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![BU of 7bav by Molmil](/molmil-images/mine/7bav) | A de novo pentameric coiled-coil assembly: CC-Type2-(TgLaId)4-W19BrPhe. | 分子名称: | CC-Type2-(TgLaId)4-W19BrPhe | 著者 | Martin, F.J.O, Dawson, W.M, Shelley, K, Brady, R.L, Woolfson, D.N. | 登録日 | 2020-12-16 | 公開日 | 2021-04-28 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states. Chem Sci, 12, 2021
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7BAW
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![BU of 7baw by Molmil](/molmil-images/mine/7baw) | A heptameric barrel state of a de novo coiled-coil assembly: CC-Type2-(GgIaId)4 | 分子名称: | CC-Type2-(GgIaId)4, GLYCEROL, N-PROPANOL | 著者 | Martin, F.J.O, Dawson, W.M, Brady, R.L, Woolfson, D.N. | 登録日 | 2020-12-16 | 公開日 | 2021-04-28 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states. Chem Sci, 12, 2021
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7EKJ
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![BU of 7ekj by Molmil](/molmil-images/mine/7ekj) | |
7BPL
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![BU of 7bpl by Molmil](/molmil-images/mine/7bpl) | Solution NMR structure of NF1; de novo designed protein with a novel fold | 分子名称: | NF1 | 著者 | Kobayashi, N, Sugiki, T, Fujiwara, T, Minami, S, Koga, R, Chikenji, G, Koga, N. | 登録日 | 2020-03-23 | 公開日 | 2021-03-24 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Exploration of novel alpha-beta-protein folds through de novo design Nat.Struct.Mol.Biol., 2023
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7RDH
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![BU of 7rdh by Molmil](/molmil-images/mine/7rdh) | |
8E55
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![BU of 8e55 by Molmil](/molmil-images/mine/8e55) | |
6YPI
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![BU of 6ypi by Molmil](/molmil-images/mine/6ypi) | Structure of the engineered metallo-Diels-Alderase DA7 W16G,K58Q,L77R,T78R | 分子名称: | 3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE, BENZOIC ACID, DA7 W16G,K58Q,L77R,T78R, ... | 著者 | Basler, S, Mori, T, Hilvert, D. | 登録日 | 2020-04-16 | 公開日 | 2021-04-28 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.479 Å) | 主引用文献 | Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold. Nat.Chem., 13, 2021
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7A1T
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![BU of 7a1t by Molmil](/molmil-images/mine/7a1t) | A collapsed hexameric state of a de novo coiled-coil assembly: CC-Type2-(GgLaId)4-W19BrPhe. | 分子名称: | ACETATE ION, CADMIUM ION, CC-Type2-(GgLaId)4-W19BrPhe, ... | 著者 | Rhys, G.G, Brady, R.L, Woolfson, D.N. | 登録日 | 2020-08-14 | 公開日 | 2021-05-19 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Coiled coils 9-to-5: rational de novo design of alpha-helical barrels with tunable oligomeric states. Chem Sci, 12, 2021
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1S48
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![BU of 1s48 by Molmil](/molmil-images/mine/1s48) | Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from BVDV | 分子名称: | RNA-dependent RNA polymerase | 著者 | Choi, K.H, Groarke, J.M, Young, D.C, Kuhn, R.J, Smith, J.L, Pevear, D.C, Rossmann, M.G. | 登録日 | 2004-01-15 | 公開日 | 2004-04-06 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation. Proc.Natl.Acad.Sci.Usa, 101, 2004
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1S4F
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![BU of 1s4f by Molmil](/molmil-images/mine/1s4f) | Crystal Structure of RNA-dependent RNA polymerase construct 2 from bovine viral diarrhea virus (BVDV) | 分子名称: | RNA-dependent RNA polymerase | 著者 | Choi, K.H, Groarke, J.M, Young, D.C, Kuhn, R.J, Smith, J.L, Pevear, D.C, Rossmann, M.G. | 登録日 | 2004-01-16 | 公開日 | 2004-04-06 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation. Proc.Natl.Acad.Sci.Usa, 101, 2004
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1S49
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![BU of 1s49 by Molmil](/molmil-images/mine/1s49) | Crystal Structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from bovine viral diarrhea virus complexed with GTP | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, RNA-dependent RNA polymerase | 著者 | Choi, K.H, Groarke, J.M, Young, D.C, Kuhn, R.J, Smith, J.L, Pevear, D.C, Rossmann, M.G. | 登録日 | 2004-01-15 | 公開日 | 2004-04-06 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation. Proc.Natl.Acad.Sci.Usa, 101, 2004
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1S9Z
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![BU of 1s9z by Molmil](/molmil-images/mine/1s9z) | SYNTHETIC 17 AMINO ACID LONG PEPTIDE THAT FORMS A NATIVE-LIKE COILED-COIL AT AMBIENT TEMPERATURE AND AGGREGATES INTO AMYLOID-LIKE FIBRILS AT HIGHER TEMPERATURES. | 分子名称: | SODIUM ION, SYNTHETIC COILED-COIL PEPTIDE, ZINC ION | 著者 | Kammerer, R.A, Kostrewa, D, Zurdo, J, Detken, A, Garcia-Echeverria, C, Green, J.D, Muller, S.A, Meier, B.H, Winkler, F.K, Dobson, C.M, Steinmetz, M.O. | 登録日 | 2004-02-06 | 公開日 | 2004-04-06 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Exploring amyloid formation by a de novo design Proc.Natl.Acad.Sci.USA, 101, 2004
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2L69
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![BU of 2l69 by Molmil](/molmil-images/mine/2l69) | Solution NMR Structure of de novo designed protein, P-loop NTPase fold, Northeast Structural Genomics Consortium Target OR28 | 分子名称: | Rossmann 2x3 fold protein | 著者 | Liu, G, Koga, N, Koga, R, Xiao, R, Mao, A, Mao, B, Patel, D, Ciccosanti, C, Hamilton, K, Acton, T.B, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2010-11-17 | 公開日 | 2011-01-12 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR structure of de novo designed rossmann 2x3 fold protein, Northeast Structural Genomics Consortium Target OR28 To be Published
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