2QRV

Structure of Dnmt3a-Dnmt3L C-terminal domain complex

Summary for 2QRV

• Entry DOI: 10.2210/pdb2qrv/pdb
• Related: 2PV0 2PVC
• Descriptor: DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3-like, S-ADENOSYL-L-HOMOCYSTEINE (3 entities in total)
• Functional Keywords: dna methyltransferase 3a (dnmt3a) and its regulatory factor, dna methyltransferase 3-like protein (dnmt3l), nucleus, s-adenosyl-l-methionine, transferase-transferase regulator complex, transferase/transferase regulator
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q9Y6K1; Nucleus (Probable): Q9UJW3
• Total number of polymer chains: 8
• Total formula weight: 244152.18

Authors

Jia, D.,Cheng, X. (deposition date: 2007-07-29, release date: 2007-12-04, Last modification date: 2023-08-30)

• Primary citation: Jia, D.,Jurkowska, R.Z.,Zhang, X.,Jeltsch, A.,Cheng, X.; Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation.; Nature, 449:248-251, 2007; PubMed: 17713477; DOI: 10.1038/nature06146

Experimental method

X-RAY DIFFRACTION (2.89 Å)