2QRV

Structure of Dnmt3a-Dnmt3L C-terminal domain complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008168	molecular_function	methyltransferase activity
D	0008168	molecular_function	methyltransferase activity
E	0008168	molecular_function	methyltransferase activity
H	0008168	molecular_function	methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SAH A 1

Chain	Residue
A	PHE636
A	ASP682
A	VAL683
A	ARG684
A	GLY703
A	PRO705
A	LEU726
A	ARG887
A	SER888
A	TRP889
A	ASP637
A	GLY638
A	ILE639
A	THR641
A	SER659
A	GLU660
A	VAL661
A	CYS662

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SAH D 4

Chain	Residue
D	PHE636
D	ASP637
D	GLY638
D	ILE639
D	THR641
D	SER659
D	GLU660
D	VAL661
D	CYS662
D	ASP682
D	VAL683
D	ARG684
D	GLY703
D	PRO705
D	LEU726
D	ARG887
D	SER888
D	TRP889

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAH E 5

Chain	Residue
E	PHE636
E	GLY638
E	ILE639
E	THR641
E	SER659
E	GLU660
E	VAL661
E	CYS662
E	ASP682
E	VAL683
E	ARG684
E	GLY703
E	PRO705
E	LEU726
E	ARG887
E	SER888
E	TRP889

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SAH H 8

Chain	Residue
H	PHE636
H	GLY638
H	ILE639
H	THR641
H	GLU660
H	VAL661
H	CYS662
H	ASP682
H	VAL683
H	GLY703
H	ARG887
H	SER888
H	TRP889

---

Functional Information from PROSITE/UniProt

site_id	PS00094
Number of Residues	13
Details	C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DlVigGsPCnDLS

Chain	Residue	Details
A	ASP698-SER710

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01016, ECO:0000255|PROSITE-ProRule:PRU10018

Chain	Residue	Details
A	LEU709
D	ILE711
E	LEU709
H	LEU709

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:17713477, ECO:0007744|PDB:2QRV

Chain	Residue	Details
A	ALA640
E	GLU663
E	SER685
E	SER890
H	ALA640
H	GLU663
H	SER685
H	SER890
A	GLU663
A	SER685
A	SER890
D	GLY642
D	SER665
D	THR687
D	PRO892
E	ALA640

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: S-methylcysteine; by autocatalysis => ECO:0000250|UniProtKB:O88508

Chain	Residue	Details
A	LEU709
D	ILE711
E	LEU709
H	LEU709

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1mht

Chain	Residue	Details
A	CYS706
A	GLU752

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1mht

Chain	Residue	Details
D	CYS706
D	GLU752

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1mht

Chain	Residue	Details
E	CYS706
E	GLU752

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1mht

Chain	Residue	Details
H	CYS706
H	GLU752

---