2QRV

Structure of Dnmt3a-Dnmt3L C-terminal domain complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008168	molecular_function	methyltransferase activity
D	0008168	molecular_function	methyltransferase activity
E	0008168	molecular_function	methyltransferase activity
H	0008168	molecular_function	methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SAH A 1

Chain	Residue
A	PHE636
A	ASP682
A	VAL683
A	ARG684
A	GLY703
A	PRO705
A	LEU726
A	ARG887
A	SER888
A	TRP889
A	ASP637
A	GLY638
A	ILE639
A	THR641
A	SER659
A	GLU660
A	VAL661
A	CYS662

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SAH D 4

Chain	Residue
D	PHE636
D	ASP637
D	GLY638
D	ILE639
D	THR641
D	SER659
D	GLU660
D	VAL661
D	CYS662
D	ASP682
D	VAL683
D	ARG684
D	GLY703
D	PRO705
D	LEU726
D	ARG887
D	SER888
D	TRP889

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAH E 5

Chain	Residue
E	PHE636
E	GLY638
E	ILE639
E	THR641
E	SER659
E	GLU660
E	VAL661
E	CYS662
E	ASP682
E	VAL683
E	ARG684
E	GLY703
E	PRO705
E	LEU726
E	ARG887
E	SER888
E	TRP889

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SAH H 8

Chain	Residue
H	PHE636
H	GLY638
H	ILE639
H	THR641
H	GLU660
H	VAL661
H	CYS662
H	ASP682
H	VAL683
H	GLY703
H	ARG887
H	SER888
H	TRP889

---

Functional Information from PROSITE/UniProt

site_id	PS00094
Number of Residues	13
Details	C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DlVigGsPCnDLS

Chain	Residue	Details
A	ASP698-SER710

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01016","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10018","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17713477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QRV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"S-methylcysteine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"O88508","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1mht

Chain	Residue	Details
A	CYS706
A	GLU752

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1mht

Chain	Residue	Details
D	CYS706
D	GLU752

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1mht

Chain	Residue	Details
E	CYS706
E	GLU752

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1mht

Chain	Residue	Details
H	CYS706
H	GLU752

---