2QRV

Structure of Dnmt3a-Dnmt3L C-terminal domain complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, E, H	DNA (cytosine-5)-methyltransferase 3A	polymer	295	33961.1	4	UniProt (Q9Y6K1) Pfam (PF00145) In PDB	Homo sapiens (human)	Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA
2	B, C, F, G	DNA (cytosine-5)-methyltransferase 3-like	polymer	230	26692.5	4	UniProt (Q9UJW3) In PDB	Homo sapiens (human)
3	A, D, E, H	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	4	Chemie (SAH)

Sequence modifications

A, D, E, H: 623 - 908 (UniProt: Q9Y6K1)

PDB	External Database	Details
Met 614	-	expression tag
Gly 615	-	expression tag
His 616	-	expression tag
His 617	-	expression tag
His 618	-	expression tag
His 619	-	expression tag
His 620	-	expression tag
His 621	-	expression tag
Met 622	-	expression tag

B, C, F, G: 160 - 386 (UniProt: Q9UJW3)

PDB	External Database	Details
Gly 157	-	expression tag
Ser 158	-	expression tag
Met 159	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	242614.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1537.6
All*	Total formula weight	244152.2

*Water molecules are not included.