6WRW

Crystal structure of computationally designed protein 2DS25.5 in complex with the human Transferrin receptor ectodomain

Summary for 6WRW

Entry DOI	10.2210/pdb6wrw/pdb
Descriptor	Transferrin receptor protein 1, Computationally designed protein 2DS25.5, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	complex, beta sheet, receptor, de novo protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	167240.80
Authors	Abraham, J.,Coscia, A.,Olal, D.,Sahtoe, D.D.,Baker, D.,Clark, L. (deposition date: 2020-04-30, release date: 2021-04-28, Last modification date: 2023-10-18)
Primary citation	Sahtoe, D.D.,Coscia, A.,Mustafaoglu, N.,Miller, L.M.,Olal, D.,Vulovic, I.,Yu, T.Y.,Goreshnik, I.,Lin, Y.R.,Clark, L.,Busch, F.,Stewart, L.,Wysocki, V.H.,Ingber, D.E.,Abraham, J.,Baker, D. Transferrin receptor targeting by de novo sheet extension. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 33879614 DOI: 10.1073/pnas.2021569118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.84 Å)

Structure validation