PDB: 1371 件ウェブページステータス検索Chemie searchBIRD

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7DVO	Structure of Reaction Intermediate of Cytochrome P450 NO Reductase (P450nor) Determined by XFEL 分子名称: GLYCEROL, NADP nitrous oxide-forming nitric oxide reductase, NITRIC OXIDE, ... 著者 Nomura, T, Kimura, T, Kanematsu, Y, Yamashita, K, Hirata, K, Ueno, G, Murakami, H, Hisano, T, Yamagiwa, R, Takeda, H, Gopalasingam, C, Yuki, K, Kousaka, R, Yanagasawa, S, Shoji, O, Kumasaka, T, Takano, Y, Ago, H, Yamamoto, M, Sugimoto, H, Tosha, T, Kubo, M, Shiro, Y. 登録日 2021-01-14 公開日 2021-05-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Short-lived intermediate in N 2 O generation by P450 NO reductase captured by time-resolved IR spectroscopy and XFEL crystallography. Proc.Natl.Acad.Sci.USA, 118, 2021
7EGN	Crystal structure of the P450 BM3 heme domain mutant F87A in complex with N-imidazolyl-hexanoyl-L-phenylalanine and hydroxylamine 分子名称: (2S)-2-(6-imidazol-1-ylhexanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, GLYCEROL, ... 著者 Jiang, Y, Dong, S, Feng, Y, Cong, Z. 登録日 2021-03-24 公開日 2021-08-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 H-Bonding Networks Dictate the Molecular Mechanism of H2O2 Activation by P450 Acs Catalysis, 11, 2021
7CCF	Mechanism insights on steroselective oxidation of phosphorylated ethylphenols with cytochrome P450 CreJ 分子名称: (3-ethylphenyl) dihydrogen phosphate, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE 著者 Dong, S, Du, L, Li, S.Y, Feng, Y.G. 登録日 2020-06-17 公開日 2021-03-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Basis for Selective Oxidation of Phosphorylated Ethylphenols by Cytochrome P450 Monooxygenase CreJ. Appl.Environ.Microbiol., 87, 2021
7E7F	Human CYP11B1 mutant in complex with metyrapone 分子名称: CHOLIC ACID, Cytochrome P450 11B1, mitochondrial, ... 著者 Mukai, K, Sugimoto, H, Reiko, S, Matsuura, T, Hishiki, T, Kagawa, N. 登録日 2021-02-26 公開日 2022-01-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis. Curr Res Struct Biol, 3, 2021
7E46	Structure of the CYP102A1 Haem Domain with N-Carboxybenzyl-L-Prolyl-L-Phenylalanine in complex with (S)-(-)-1-Phenylethylamine 分子名称: (1S)-1-phenylethanamine, (2S)-3-phenyl-2-[[(2S)-1-phenylmethoxycarbonylpyrrolidin-2-yl]carbonylamino]propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, ... 著者 Stanfield, J.K, Sugimoto, H, Shoji, O. 登録日 2021-02-10 公開日 2022-02-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Structure of the CYP102A1 Haem Domain with N-Carboxybenzyl-L-Prolyl-L-Phenylalanine in complex with (S)-(-)-1-Phenylethylamine at 1.91 Angstrom Resolution To Be Published
7F3H	Crystal structure of cytochrome P450DA heme domain 分子名称: Bifunctional cytochrome P450/NADPH--P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, SERINE, ... 著者 Wan, N.W. 登録日 2021-06-16 公開日 2021-07-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Directed evolution of cytochrome P450DA hydroxylase activity for stereoselective biohydroxylation Catalysis Science And Technology, 12, 2022
5FOI	Crystal structure of mycinamicin VIII C21 methyl hydroxylase MycCI from Micromonospora griseorubida bound to mycinamicin VIII 分子名称: GLYCEROL, MYCINAMICIN VIII C21 METHYL HYDROXYLASE, Mycinamicin VIII, ... 著者 Demars, M, Sheng, F, Podust, L.M, Sherman, D.H. 登録日 2015-11-22 公開日 2016-07-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Biochemical and Structural Characterization of Mycci, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway. Acs Chem.Biol., 11, 2016
5VBU	Crystal Structure of Human Cytochrome P450 21A2 Hydroxyprogesterone Complex 分子名称: (9beta)-17-hydroxypregn-4-ene-3,20-dione, Cytochrome P450 21-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE 著者 Pallan, P.S, Egli, M. 登録日 2017-03-30 公開日 2017-05-31 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (3.31 Å) 主引用文献 Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia. J. Biol. Chem., 292, 2017
5GNL	Cytochrome P450 Vdh (CYP107BR1) F106V mutant 分子名称: 2-(2-METHOXYETHOXY)ETHANOL, PROTOPORPHYRIN IX CONTAINING FE, Vitamin D(3) 25-hydroxylase 著者 Yasutake, Y, Tamura, T. 登録日 2016-07-22 公開日 2017-05-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural insights into the mechanism of the drastic changes in enzymatic activity of the cytochrome P450 vitamin D3 hydroxylase (CYP107BR1) caused by a mutation distant from the active site Acta Crystallogr F Struct Biol Commun, 73, 2017
1EHE	CRYSTAL STRUCTURES OF CYTOCHROME P450NOR AND ITS MUTANTS (SER286 VAL, THR) IN THE FERRIC RESTING STATE AT CRYOGENIC TEMPERATURE: A COMPARATIVE ANALYSIS WITH MONOOXYGENASE CYTOCHROME P450S 分子名称: CYTOCHROME P450NOR, PROTOPORPHYRIN IX CONTAINING FE 著者 Shimizu, H, Park, S. 登録日 2000-02-21 公開日 2000-08-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structures of cytochrome P450nor and its mutants (Ser286-->Val, Thr) in the ferric resting state at cryogenic temperature: a comparative analysis with monooxygenase cytochrome P450s. J.Inorg.Biochem., 81, 2000
5G5J	Crystal structure of human CYP3A4 bound to metformin 分子名称: CYTOCHROME P450 3A4, Metformin, PROTOPORPHYRIN IX CONTAINING FE 著者 Sevrioukova, I. 登録日 2016-05-25 公開日 2017-06-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chem Biol, 24, 2017
5VWS	Ligand free structure of Cytochrome P450 TbtJ1 分子名称: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE 著者 Gober, J.G, Ghodge, S.V, Brustad, E.M, Bowers, A.A. 登録日 2017-05-22 公開日 2017-06-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.411 Å) 主引用文献 P450-Mediated Non-natural Cyclopropanation of Dehydroalanine-Containing Thiopeptides. ACS Chem. Biol., 12, 2017
1F24	CRYSTAL STRUCTURE OF NO COMPLEX OF THR243ALA MUTANTS OF CYTOCHROME P450NOR 分子名称: GLYCEROL, NITRIC OXIDE, NITRIC OXIDE REDUCTASE, ... 著者 Shimizu, H, Park, S.-Y. 登録日 2000-05-23 公開日 2000-11-23 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Mutation effects of a conserved threonine (Thr243) of cytochrome P450nor on its structure and function. J.Inorg.Biochem., 82, 2000
1F25	CRYSTAL STRUCTURE OF NO COMPLEX OF THR243ASN MUTANTS OF CYTOCHROME P450NOR 分子名称: GLYCEROL, NITRIC OXIDE, NITRIC OXIDE REDUCTASE, ... 著者 Shimizu, H, Park, S.-Y. 登録日 2000-05-23 公開日 2000-11-23 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Mutation effects of a conserved threonine (Thr243) of cytochrome P450nor on its structure and function. J.Inorg.Biochem., 82, 2000
1F26	CRYSTAL STRUCTURE OF NO COMPLEX OF THR243VAL MUTANTS OF CYTOCHROME P450NOR 分子名称: GLYCEROL, NITRIC OXIDE, NITRIC OXIDE REDUCTASE, ... 著者 Shimizu, H, Park, S.-Y. 登録日 2000-05-23 公開日 2000-11-23 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Mutation effects of a conserved threonine (Thr243) of cytochrome P450nor on its structure and function. J.Inorg.Biochem., 82, 2000
1F4U	THERMOPHILIC P450: CYP119 FROM SULFOLOBUS SOLFACTARICUS 分子名称: CYTOCHROME P450 119, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Yano, J.K, Koo, L.S, Schuller, D.J, Li, H, Ortiz de Montellano, P.R, Poulos, T.L. 登録日 2000-06-09 公開日 2000-10-23 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Crystal structure of a thermophilic cytochrome P450 from the archaeon Sulfolobus solfataricus. J.Biol.Chem., 275, 2000
5GWE	cytochrome P450 CREJ 分子名称: (4-methylphenyl) dihydrogen phosphate, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Dong, S, liu, X, Wang, X, Feng, Y. 登録日 2016-09-11 公開日 2017-07-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Selective oxidation of aliphatic C-H bonds in alkylphenols by a chemomimetic biocatalytic system Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5H1Z	CYP153D17 from Sphingomonas sp. PAMC 26605 分子名称: DODECANE, PROTOPORPHYRIN IX CONTAINING FE, putative CYP alkane hydroxylase CYP153D17 著者 Lee, C.W, Lee, J.H. 登録日 2016-10-13 公開日 2017-01-11 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal Structure of a Putative Cytochrome P450 Alkane Hydroxylase (CYP153D17) from Sphingomonas sp. PAMC 26605 and Its Conformational Substrate Binding Int J Mol Sci, 17, 2016
1H5Z	CYTOCHROME P450 14 ALPHA-STEROL DEMETHYLASE (CYP51) FROM MYCOBACTERIUM TUBERCULOSIS IN FERRIC LOW-SPIN STATE 分子名称: CYTOCHROME P450 51, FE (II) ION, PROTOPORPHYRIN IX CONTAINING FE 著者 Podust, L.M, Arase, M, Waterman, M.R. 登録日 2001-05-31 公開日 2003-10-03 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Estriol Bound and Ligand-Free Structures of Sterol 14Alpha-Demethylase. Structure, 12, 2004
5VC0	Crystal structure of human CYP3A4 bound to ritonavir 分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, RITONAVIR 著者 Sevrioukova, I. 登録日 2017-03-30 公開日 2017-05-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4. Biochemistry, 56, 2017
5VCE	Crystal structure of the cysteine depleted CYP3A4 bound to ritonavir 分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, RITONAVIR 著者 Sevrioukova, I. 登録日 2017-03-31 公開日 2017-05-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4. Biochemistry, 56, 2017
5W0C	Cytochrome P450 (CYP) 2C9 TCA007 Inhibitor Complex 分子名称: Cytochrome P450 2C9, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Johnson, E.F, Hsu, M.-H. 登録日 2017-05-30 公開日 2017-09-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes. Angew. Chem. Int. Ed. Engl., 56, 2017
5X24	Crystal structure of CYP2C9 genetic variant I359L (*3) in complex with multiple losartan molecules 分子名称: Cytochrome P450 2C9, PHOSPHATE ION, POTASSIUM ION, ... 著者 Maekawa, K, Adachi, M, Shah, M.B. 登録日 2017-01-30 公開日 2017-10-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9 Biochemistry, 56, 2017
5HDI	Structural characterization of CYP144A1, a Mycobacterium tuberculosis cytochrome P450 分子名称: Cytochrome P450 144, PROTOPORPHYRIN IX CONTAINING FE 著者 Chenge, J, Driscoll, M.D, McLean, K.J, Munro, A.W, Leys, D. 登録日 2016-01-05 公開日 2016-05-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis. Sci Rep, 6, 2016
5HH3	OxyA from Actinoplanes teichomyceticus 分子名称: ACETATE ION, GLYCEROL, OxyA protein, ... 著者 Haslinger, K, Cryle, M.J. 登録日 2016-01-09 公開日 2016-02-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of OxyAtei : completing our picture of the glycopeptide antibiotic producing Cytochrome P450 cascade. Febs Lett., 590, 2016

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