3IBD
Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole
Summary for 3IBD
Entry DOI | 10.2210/pdb3ibd/pdb |
Descriptor | Cytochrome P450 2B6, PROTOPORPHYRIN IX CONTAINING FE, 4-(4-CHLOROPHENYL)IMIDAZOLE, ... (6 entities in total) |
Functional Keywords | p450, cytochrome p450 2b6, monooxygenase, oxidoreductase, membrane protein, cyp 2b6, endoplasmic reticulum, heme, iron, membrane, metal-binding, microsome, phosphoprotein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P20813 |
Total number of polymer chains | 1 |
Total formula weight | 56662.58 |
Authors | Gay, S.C.,Sun, L.,Talakad, J.C.,Shah, M.B.,Stout, D.C.,Halpert, J.R. (deposition date: 2009-07-15, release date: 2010-01-19, Last modification date: 2023-09-06) |
Primary citation | Gay, S.C.,Shah, M.B.,Talakad, J.C.,Maekawa, K.,Roberts, A.G.,Wilderman, P.R.,Sun, L.,Yang, J.Y.,Huelga, S.C.,Hong, W.X.,Zhang, Q.,Stout, C.D.,Halpert, J.R. Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution. Mol.Pharmacol., 77:529-538, 2010 Cited by PubMed: 20061448DOI: 10.1124/mol.109.062570 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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