3IBD

Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole

Summary for 3IBD

• Entry DOI: 10.2210/pdb3ibd/pdb
• Descriptor: Cytochrome P450 2B6, PROTOPORPHYRIN IX CONTAINING FE, 4-(4-CHLOROPHENYL)IMIDAZOLE, ... (6 entities in total)
• Functional Keywords: p450, cytochrome p450 2b6, monooxygenase, oxidoreductase, membrane protein, cyp 2b6, endoplasmic reticulum, heme, iron, membrane, metal-binding, microsome, phosphoprotein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein: P20813
• Total number of polymer chains: 1
• Total formula weight: 56662.58

Authors

Gay, S.C.,Sun, L.,Talakad, J.C.,Shah, M.B.,Stout, D.C.,Halpert, J.R. (deposition date: 2009-07-15, release date: 2010-01-19, Last modification date: 2023-09-06)

• Primary citation: Gay, S.C.,Shah, M.B.,Talakad, J.C.,Maekawa, K.,Roberts, A.G.,Wilderman, P.R.,Sun, L.,Yang, J.Y.,Huelga, S.C.,Hong, W.X.,Zhang, Q.,Stout, C.D.,Halpert, J.R.; Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.; Mol.Pharmacol., 77:529-538, 2010; PubMed: 20061448; DOI: 10.1124/mol.109.062570

Experimental method

X-RAY DIFFRACTION (2 Å)