6F0B

Cytochrome P450 TxtC employs substrate conformational switching for sequential aliphatic and aromatic thaxtomin hydroxylation

Summary for 6F0B

Entry DOI	10.2210/pdb6f0b/pdb
Descriptor	Cytochrome P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, (3~{S},6~{S})-1,4-dimethyl-3-[(4-nitro-1~{H}-indol-3-yl)methyl]-6-(phenylmethyl)piperazine-2,5-dione, ... (4 entities in total)
Functional Keywords	cytochrome p450, txtc, thaxtomin hydroxylation, oxidoreductase
Biological source	Streptomyces acidiscabies 84-104
Total number of polymer chains	1
Total formula weight	44494.30
Authors	Fulop, V. (deposition date: 2017-11-17, release date: 2018-12-12, Last modification date: 2024-01-17)
Primary citation	Alkhalaf, L.M.,Barry, S.M.,Rea, D.,Gallo, A.,Griffiths, D.,Lewandowski, J.R.,Fulop, V.,Challis, G.L. Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC. J.Am.Chem.Soc., 141:216-222, 2019 Cited by PubMed: 30516965 DOI: 10.1021/jacs.8b08864 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation