3KSW

Crystal structure of sterol 14alpha-demethylase (CYP51) from Trypanosoma cruzi in complex with an inhibitor VNF ((4-(4-chlorophenyl)-N-[2-(1H-imidazol-1-yl)-1-phenylethyl]benzamide)

Summary for 3KSW

Entry DOI	10.2210/pdb3ksw/pdb
Related	3K1O 3KHM
Descriptor	Sterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 4'-chloro-N-[(1R)-2-(1H-imidazol-1-yl)-1-phenylethyl]biphenyl-4-carboxamide (3 entities in total)
Functional Keywords	sterol 14-alpha demethylase, cyp51, cytochrome p450, heme, oxidoreductase, monooxygenase, endoplasmic reticulum, transmembrane protein, sterol biosynthesis, lipids, membrane, iron, heme thiolate protein, lipid synthesis, metal-binding, nadp, steroid biosynthesis
Biological source	Trypanosoma cruzi
Cellular location	Membrane; Single-pass membrane protein (Potential): Q5I4E1
Total number of polymer chains	1
Total formula weight	53371.02
Authors	Lepesheva, G.I.,Hargrove, T.Y.,Anderson, S.,Wawrzak, Z.,Waterman, M.R. (deposition date: 2009-11-23, release date: 2009-12-01, Last modification date: 2023-09-06)
Primary citation	Lepesheva, G.I.,Hargrove, T.Y.,Anderson, S.,Kleshchenko, Y.,Furtak, V.,Wawrzak, Z.,Villalta, F.,Waterman, M.R. Structural Insights into Inhibition of Sterol 14{alpha}-Demethylase in the Human Pathogen Trypanosoma cruzi. J.Biol.Chem., 285:25582-25590, 2010 Cited by PubMed: 20530488 DOI: 10.1074/jbc.M110.133215 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.05 Å)

Structure validation