3KHM

Crystal structure of sterol 14alpha-demethylase (CYP51) from Trypanosoma cruzi in complex with inhibitor fluconazole

Summary for 3KHM

Entry DOI	10.2210/pdb3khm/pdb
Related	3K1O
Descriptor	Sterol 14 alpha-demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL (3 entities in total)
Functional Keywords	sterol 14-alpha demethylase, cyp51, cytochrome p450, heme, oxidoreductase, monooxygenase, endoplasmic reticulum, transmembrane protein, sterol biosynthesis, lipids, membrane, iron, heme thiolate protein
Biological source	Trypanosoma cruzi
Total number of polymer chains	1
Total formula weight	53848.10
Authors	Lepesheva, G.I.,Hargrove, T.Y.,Anderson, S.,Wawrzak, Z.,Waterman, M.R. (deposition date: 2009-10-30, release date: 2009-11-10, Last modification date: 2023-09-06)
Primary citation	Lepesheva, G.I.,Hargrove, T.Y.,Anderson, S.,Kleshchenko, Y.,Furtak, V.,Wawrzak, Z.,Villalta, F.,Waterman, M.R. Structural Insights into Inhibition of Sterol 14{alpha}-Demethylase in the Human Pathogen Trypanosoma cruzi. J.Biol.Chem., 285:25582-25590, 2010 Cited by PubMed: 20530488 DOI: 10.1074/jbc.M110.133215 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation