3KHM
Crystal structure of sterol 14alpha-demethylase (CYP51) from Trypanosoma cruzi in complex with inhibitor fluconazole
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Sterol 14 alpha-demethylase | polymer | 464 | 52925.3 | 1 | UniProt (Q5I4E1) Pfam (PF00067) UniProt (by SIFTS) (Q7Z1V1) In PDB | Trypanosoma cruzi | |
2 | A | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
3 | A | 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL | non-polymer | 306.3 | 1 | Chemie (TPF) |
Sequence modifications
A: 24 - 481 (UniProt: Q5I4E1)
PDB | External Database | Details |
---|---|---|
Lys 24 | Phe 24 | engineered mutation |
Thr 25 | Asn 25 | engineered mutation |
Ser 26 | Thr 26 | engineered mutation |
Gly 27 | Thr 27 | engineered mutation |
Lys 28 | Arg 28 | engineered mutation |
Gly 29 | Pro 29 | engineered mutation |
Lys 30 | Thr 30 | engineered mutation |
Leu 31 | Asp 31 | engineered mutation |
His 482 | - | expression tag |
His 483 | - | expression tag |
His 484 | - | expression tag |
His 485 | - | expression tag |
His 486 | - | expression tag |
His 487 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 52925.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 922.8 | |
All* | Total formula weight | 53848.1 |