6E8Q
S. CEREVISIAE CYP51 COMPLEXED WITH Posaconazole
Summary for 6E8Q
Entry DOI | 10.2210/pdb6e8q/pdb |
Related | 5UL0 |
Descriptor | Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, POSACONAZOLE, ... (6 entities in total) |
Functional Keywords | posaconazole, cyp51, sterol biosynthesis, oxidoreductase |
Biological source | Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) |
Total number of polymer chains | 1 |
Total formula weight | 63951.37 |
Authors | Tyndall, J.D.,Keniya, M.V.,Sabherwal, M.,Monk, B.C. (deposition date: 2018-07-30, release date: 2018-09-05, Last modification date: 2023-10-11) |
Primary citation | Monk, B.C.,Keniya, M.V.,Sabherwal, M.,Wilson, R.K.,Graham, D.O.,Hassan, H.F.,Chen, D.,Tyndall, J.D.A. Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161. Antimicrob. Agents Chemother., 63:-, 2019 Cited by PubMed: 30397057DOI: 10.1128/AAC.02114-18 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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