3L4D

Crystal structure of sterol 14-alpha demethylase (CYP51) from Leishmania infantum in complex with fluconazole

Summary for 3L4D

Entry DOI	10.2210/pdb3l4d/pdb
Descriptor	Sterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (5 entities in total)
Functional Keywords	sterol 14-alpha demethylase, cyp51, p450, heme, oxidoreductase, monooxygenase, endoplasmic reticulum, transmembrane protein, sterol biosynthesis, obtusifoliol, lipids, membrane, iron
Biological source	Leishmania infantum
Total number of polymer chains	4
Total formula weight	208795.23
Authors	Lepesheva, G.I.,Hargrove, T.Y.,Wawrzak, Z.,Waterman, M.R. (deposition date: 2009-12-19, release date: 2009-12-29, Last modification date: 2023-09-06)
Primary citation	Hargrove, T.Y.,Wawrzak, Z.,Liu, J.,Nes, W.D.,Waterman, M.R.,Lepesheva, G.I. Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14{alpha}-Demethylase (CYP51) from Leishmania infantum. J.Biol.Chem., 286:26838-26848, 2011 Cited by PubMed: 21632531 DOI: 10.1074/jbc.M111.237099 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation